A therapeutic anti-Streptococcus mutans monoclonal antibody used in human passive protection trials influences the adaptive immune response.
A therapeutic anti-Streptococcus mutans monoclonal antibody used in human passive protection trials influences the adaptive immune response.
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用于人类被动保护试验的治疗性抗变形链球菌单克隆抗体会影响适应性免疫反应。
DOI：
10.1016/j.vaccine.2011.06.027
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发表时间：
2011
期刊：
影响因子：
5.5
通讯作者：
Brady,LJeannine
中科院分区：
文献类型：
--
作者：
Robinette,RebekahA;Oli,MonikaW;McArthur,WilliamP;Brady,LJeannine
致龋性牙源性致病菌变形链球菌的粘附素（Antigen I/II，P1或PAc）是保护性免疫的靶标和候选疫苗抗原。以前我们证明了用S.与单独施用细菌相比，与抗AgI/II单克隆抗体（MAbs）复合的变形杆菌导致免疫小鼠血清中引发的抗AgI/II抗体的特异性、同种型和功能性的变化。在目前的研究中，文献中报道的抗AgI/II单克隆抗体对S.在人临床试验中被动免疫后，评价了MAb Guy's 13（MAb Guy's 13 plantibody）的变形杆菌再定殖，并在烟草植物中表达（MAb Guy's 13 plantibody），以评价其潜在的免疫调节特性。Guy ′ s 13植物抗体与S.变异株全细胞导致了与其它免疫调节单克隆抗体相似的特异性、同种型和功能性的变化。这一新的信息，加上最近解决的粘附素的晶体结构，现在提供了一个合理的解释和合理的机制，被动管理的盖伊13/盖伊13 plantibody在人类临床试验中的作用，以及如何长期预防S。可以实现在治疗性抗体的应用期之后很好地携带变异株。
The adhesin known as Antigen I/II, P1 or PAc of the cariogenic dental pathogen Streptococcus mutans is a target of protective immunity and candidate vaccine antigen. Previously we demonstrated that immunization of mice with S. mutans complexed with anti-AgI/II monoclonal antibodies (MAbs) resulted in changes in the specificity, isotype and functionality of elicited anti-AgI/II antibodies in the serum of immunized mice compared to administration of bacteria alone. In the current study, an anti-AgI/II MAb reported in the literature to confer unexplained long term protection against S. mutans re-colonization following passive immunization in human clinical trials (MAb Guy's 13), and expressed in tobacco plants (MAb Guy's 13 plantibody), was evaluated for its potential immunomodulatory properties. Immunization of BALB/c mice with immune complexes of Guy's 13 plantibody bound to S. mutans whole cells resulted in a similar change in specificity, isotype, and functionality of elicited anti-AgI/II antibodies as had been observed for other immunomodulatory MAbs. This new information, coupled with the recently solved crystal structure of the adhesin, now provides a rational explanation and plausible mechanism of action of passively administered Guy's 13/Guy's 13 plantibody in human clinical trials, and how long-term prevention of S. mutans carriage well past the application period of the therapeutic antibody could have been achieved.
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使用来自变形链球菌的纯化蛋白抗原对恒河猴进行抗龋齿免疫
影响因子：
3.1
作者：
T. Lehner;M. Russell;J. Caldwell;R. Smith
通讯作者：
R. Smith
影响因子：
3.1
作者：
Loimaranta, V;Jakubovics, NS;Strömberg, N
通讯作者：
Strömberg, N
链球菌抗原I/II单克隆抗体局部被动免疫预防龋齿
影响因子：
3.1
作者：
T. Lehner;J. Caldwell;R. Smith
通讯作者：
R. Smith
抗变形链球菌 P1 单克隆抗体识别表位的表征。
影响因子：
--
作者：
McArthur,WilliamP;Rhodin,NikkiR;Seifert,TrevorB;Oli,MonikaW;Robinette,RebekahA;Demuth,DonaldR;Brady,LJeannine
通讯作者：
Brady,LJeannine
龋齿疫苗的开发和前景。
DOI：
10.1177/10454411900010010401
发表时间：
1990
期刊：
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists
影响因子：
--
作者：
Michalek,SM;Childers,NK
通讯作者：
Childers,NK