Intratumoral and peritumoral lymphatic vessel density both correlate with lymph node metastasis in breast cancer.
Intratumoral and peritumoral lymphatic vessel density both correlate with lymph node metastasis in breast cancer.
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瘤内和瘤周淋巴管密度均与乳腺癌淋巴结转移相关
DOI：
10.1038/srep40364
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发表时间：
2017-01-09
影响因子：
4.6
通讯作者：
Zou L
中科院分区：
文献类型：
--
作者：
Zhang S;Yi S;Zhang D;Gong M;Cai Y;Zou L
淋巴结受累状况是乳腺癌的重要预后因素。然而，原发性肿瘤病灶中是否存在瘤内淋巴管以及淋巴管密度（LVD）与淋巴结转移（LNM）之间的关系尚未明确。因此，我们进行了荟萃分析研究来调查这些问题。根据预先制定的纳入和排除标准，本研究纳入了13项研究，涉及1029名乳腺癌患者。采用免疫组织化学染色，40.07%（240/599）的乳腺癌患者检出瘤内淋巴管，77.09%（397/515）检出瘤周淋巴管。所有研究均表明瘤周 LVD 高于瘤内 LVD，合并标准均值差和 95% 置信区间 (95% CI) 为 1.75（1.28 至 2.21）。瘤内LVD和瘤周LVD均与LNM呈正相关，相关系数分别为0.14（95% CI 0.05至0.23）和0.31（95% CI 0.13至0.49）。总之，我们的研究报告了肿瘤内淋巴管的总体检出率，并证明了乳腺癌中肿瘤内 LVD、肿瘤周围 LVD 和 LNM 之间的关联。此外，需要对大量受试者进行对照研究来建立这些关系。
The status of lymph node involvement is an important prognostic factor for breast cancer. However, the presence of intratumoral lymphatic vessels in primary tumor lesions and the relationship between lymphatic vessel density (LVD) and lymph node metastasis (LNM) have not been firmly established. Therefore, we performed a meta-analysis study to investigate these issues. According to the pre-established inclusion and exclusion criteria, 13 studies, involving 1029 breast cancer patients, were included in this study. Using immunohistochemical staining, intratumoral lymphatic vessels were detected in 40.07% of breast cancer patients (240/599), and peritumoral lymphatics were detected in 77.09% (397/515). All studies demonstrated that peritumoral LVD was higher than intratumoral LVD, with a pooled standard mean difference and 95% confidence interval (95% CI) of 1.75 (1.28 to 2.21). Both intratumoral LVD and peritumoral LVD positively correlated with LNM, with correlation coefficients of 0.14 (95% CI 0.05 to 0.23) and 0.31 (95% CI 0.13 to 0.49), respectively. In summary, our study reports the overall detection rate of intratumoral lymphatics and demonstrates the associations between intratumoral LVD, peritumoral LVD, and LNM in breast cancer. Additionally, controlled studies with a larger number of subjects are needed to establish these relationships.
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影响因子：
8.8
作者：
Van der Auwera, I;Cao, Y;Tille, J C;Pepper, M S;Jackson, D G;Fox, S B;Harris, A L;Dirix, L Y;Vermeulen, P B
通讯作者：
Vermeulen, P B
影响因子：
82.9
作者：
Skobe, M;Hawighorst, T;Detmar, M
通讯作者：
Detmar, M
影响因子：
7.5
作者：
Saad, Reda S.;Kordunsky, Lana;Silverman, Jan F.
通讯作者：
Silverman, Jan F.
影响因子：
11.5
作者：
Van der Auwera, I;Van den Eynden, GG;Vermeulen, PB
通讯作者：
Vermeulen, PB
DOI：
10.1196/annals.1413.020
发表时间：
2008-01-01
期刊：
LYMPHATIC CONTINUUM REVISITED
影响因子：
--
作者：
Achen, Marc G.;Stacker, Steven A.
通讯作者：
Stacker, Steven A.