Uncertainty around the Long-Term Implications of COVID-19.

Uncertainty around the Long-Term Implications of COVID-19.
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Covid-19的长期影响的不确定性。

DOI:
10.3390/pathogens10101267
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发表时间:
2021-10-01
期刊:
Pathogens (Basel, Switzerland)
影响因子:
--
通讯作者:
Leonardi AJ
Leonardi AJ
中科院分区:
其他
文献类型:
--
作者:
Desforges M;Gurdasani D;Hamdy A;Leonardi AJ

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严重急性呼吸综合征冠状病毒2(SARS-CoV-2)已感染全球2.31亿人,截至2021年9月26日,世界卫生组织记录的死亡人数超过470万人。为了应对大流行,一些国家(新西兰、越南、台湾、韩国和其他国家)采取了遏制战略,即所谓的零冠状病毒政策,以推动和保持感染率尽可能接近于零,并积极应对新病例。相比之下,欧洲国家和北美采取了缓解战略(强度和有效性各不相同),主要目的是防止卫生系统不堪重负。随着我们对SARS-CoV-2及其生物学的了解的最新进展,以及人们越来越多地认识到新冠肺炎除了急性感染之外还有更多的风险,我们对突变逃逸、病毒持久性、再感染、免疫调节失调以及神经系统和多系统并发症(长冠状病毒病)的一些长期风险进行了展望。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 231 million people globally, with more than 4.7 million deaths recorded by the World Health Organization as of 26 September 2021. In response to the pandemic, some countries (New Zealand, Vietnam, Taiwan, South Korea and others) have pursued suppression strategies, so-called Zero COVID policies, to drive and maintain infection rates as close to zero as possible and respond aggressively to new cases. In comparison, European countries and North America have adopted mitigation strategies (of varying intensity and effectiveness) that aim primarily to prevent health systems from being overwhelmed. With recent advances in our understanding of SARS-CoV-2 and its biology, and the increasing recognition there is more to COVID-19 beyond the acute infection, we offer a perspective on some of the long-term risks of mutational escape, viral persistence, reinfection, immune dysregulation and neurological and multi-system complications (Long COVID).
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