In utero arsenic exposure and infant infection in a United States cohort: a prospective study.
In utero arsenic exposure and infant infection in a United States cohort: a prospective study.
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DOI：
10.1016/j.envres.2013.05.001
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发表时间：
2013-10
影响因子：
8.3
通讯作者：
Karagas, Margaret R.
中科院分区：
文献类型：
--
作者：
Farzan, Shohreh F.;Korrick, Susan;Li, Zhigang;Enelow, Richard;Gandolfi, A. Jay;Madan, Juliette;Nadeau, Kari;Karagas, Margaret R.
砷（As）是一种普遍存在的环境毒物，最近被认为与高暴露人群的免疫功能紊乱和感染易感性增强有关。在我们的美国研究区域，砷含量高于EPA最大污染物水平，这对孕妇和婴儿来说是一个特别的健康问题。作为新罕布什尔州出生队列研究的一部分，我们调查了子宫内接触砷是否会影响婴儿感染的风险。我们前瞻性地获得了关于4个月大婴儿（n=214）的信息，使用父母电话调查婴儿的感染和症状，包括呼吸道感染，腹泻和特定疾病，以及感染的持续时间和严重程度。使用逻辑回归和泊松模型，我们评估了孕妇在怀孕期间尿砷和潜在的混杂因素调整后的感染风险之间的关联。孕妇尿砷浓度与需要就诊的感染总数有关（尿液中As每增加1倍的相对风险（RR）=1.5; 95%置信区间（CI）=1.0，2.1）或处方药（RR=1.6; 95% CI =1.1，2.4），以及接受处方药治疗的下呼吸道感染（RR=3.3; 95% CI =1.2，9.0）。观察到与呼吸道症状（RR=4.0; 95% CI =1.0，15.8）、上呼吸道感染（RR=1.6; 95% CI =1.0，2.5）和处方药治疗的感冒（RR=2.3; 95% CI =1.0，5.2）相关。我们的研究结果提供了初步的证据表明，在子宫内作为暴露可能与婴儿感染和感染的严重程度，并提供洞察胎儿作为暴露的早期生活的影响。
Arsenic (As), a ubiquitous environmental toxicant, has recently been linked to disrupted immune function and enhanced infection susceptibility in highly exposed populations. Drinking water As levels above the EPA maximum contaminant level occur in our US study area and are a particular health concern for pregnant women and infants. As part of the New Hampshire Birth Cohort Study, we investigated whether in utero exposure to As affects risk of infant infections. We prospectively obtained information on four-month-old infants (n=214) using a parental telephone survey on infant’s infections and symptoms, including respiratory infections, diarrhea and specific illnesses, as well as the duration and severity of infections. Using logistic regression and Poisson models, we evaluated the association between maternal urinary As during pregnancy and infection risks adjusted for potentially confounding factors. Maternal urinary As concentrations were related to total number of infections requiring a physician visit (Relative Risk (RR) per one-fold increase in As in urine =1.5; 95% confidence interval (CI)=1.0, 2.1) or prescription medication (RR=1.6; 95% CI =1.1, 2.4), as well as lower respiratory infections treated with prescription medication (RR=3.3; 95% CI =1.2, 9.0). Associations were observed with respiratory symptoms (RR=4.0; 95% CI =1.0, 15.8), upper respiratory infections (RR=1.6; 95% CI =1.0, 2.5), and colds treated with prescription medication (RR=2.3; 95% CI =1.0, 5.2). Our results provide initial evidence that in utero As exposure may be related to infant infection and infection severity and provide insight into the early life impacts of fetal As exposure.
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DOI：
10.1351/pac-con-11-09-17
发表时间：
2012
期刊：
Pure and applied chemistry. Chimie pure et appliquee
影响因子：
--
作者：
Jackson BP;Taylor VF;Punshon T;Cottingham KL
通讯作者：
Cottingham KL
影响因子：
4.5
作者：
Fry RC;Navasumrit P;Valiathan C;Svensson JP;Hogan BJ;Luo M;Bhattacharya S;Kandjanapa K;Soontararuks S;Nookabkaew S;Mahidol C;Ruchirawat M;Samson LD
通讯作者：
Samson LD
影响因子：
10.4
作者：
Jackson BP;Taylor VF;Karagas MR;Punshon T;Cottingham KL
通讯作者：
Cottingham KL
DOI：
10.1097/jom.0b013e3181566ba0
发表时间：
2007-10-01
影响因子：
3.2
作者：
Huyck, Karen L.;Kile, Molly L.;Christiani, David C.
通讯作者：
Christiani, David C.
影响因子：
5.4
作者：
Hopenhayn, C;Ferreccio, C;Hertz-Picciotto, I
通讯作者：
Hertz-Picciotto, I