Automated-parameterization of the motor evoked potential and cortical silent period induced by transcranial magnetic stimulation.

Automated-parameterization of the motor evoked potential and cortical silent period induced by transcranial magnetic stimulation.
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DOI:
10.1016/j.clinph.2009.04.020
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发表时间:
2009-08
期刊:
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子:
--
通讯作者:
Fox PT
Fox PT
中科院分区:
其他
文献类型:
--
作者:
Rábago CA;Lancaster JL;Narayana S;Zhang W;Fox PT

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标准化经颅磁刺激 (TMS) 引发的运动诱发电位 (MEP) 和皮质静默期 (CSP) 记录的表征。开发并测试了基于计算机的自动参数化程序 (APP),该程序提供了一套全面的肌电图 (EMG) 幅度和时间测量值。使用来自健康成年人群 (N = 13) 的 MEP、CSP 和隔离 CSP (iCSP) TMS 刺激响应数据对 APP 进行了测试。与两种著名的自动化方法相比,APP 在 CSP 偏移时间方面具有最高的内部可靠性(Cronbach’s alpha = .98)。 CSP 后肌电图恢复水平比 TMS 前肌电图水平高 49%。 MEP 大小(峰值幅度、平均幅度、峰峰值幅度和面积)与有效电场 (Eeff) 的相关性高于其他强度测量(r ≈ 0.5 与 r ≈ 0.3),这表明 Eeff 更适合标准化 MEP 刺激-响应关系。 APP 成功地描述了包含 MEP、CSP 和 iCSP 响应的个体和平均时期。该应用程序提供了与之前的研究一致的通用信号和时间测量以及新颖的附加参数。意义:通过使用 APP 建模方法和 Eeff,可以实现用于分析和报告 MEP-CSP 复合体和 iCSP 测量的标准方法。
To standardize the characterization of motor evoked potential (MEP) and cortical silent period (CSP) recordings elicited with transcranial magnetic stimulation (TMS). A computer-based, automated-parameterization program (APP) was developed and tested which provides a comprehensive set of electromyography (EMG) magnitude and temporal measures. The APP was tested using MEP, CSP, and isolated CSP (iCSP) TMS stimulus-response data from a healthy adult population (N = 13). The APP had the highest internal reliability (Cronbach’s alpha = .98) for CSP offset time compared with two prominent automated methods. The immediate post-CSP EMG recovery level was 49% higher than the pre-TMS EMG level. MEP size (peak amplitude, mean amplitude, peak-to-peak amplitude, and area) correlated higher with effective E-field (Eeff) than other intensity measures (r ≈ 0.5 vs. r ≈ 0.3) suggesting that Eeff is better suited for standardizing MEP stimulus-response relationships. The APP successfully characterized individual and mean epochs containing MEP, CSP, and iCSP responses. The APP provided common signal and temporal measures consistent with previous studies and novel additional parameters. Significance: With the use of the APP modeling method and the Eeff, a standard approach for the analysis and reporting of MEP-CSP complex and iCSP measurements is achievable.
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