Revisiting the hippocampal-amygdala pathway in primates: association with immature-appearing neurons.
Revisiting the hippocampal-amygdala pathway in primates: association with immature-appearing neurons.
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DOI：
10.1016/j.neuroscience.2012.03.040
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发表时间：
2012-06-14
期刊：
影响因子：
3.3
通讯作者：
Becoats, K. T.
中科院分区：
文献类型：
--
作者：
Fudge, J. L.;Decampo, D. M.;Becoats, K. T.
关键词：
对“恐惧回路”的阐明为理解和治疗人类焦虑症开辟了令人兴奋的途径。然而，将啮齿动物研究转化为人类研究，反之亦然，取决于对跨物种相关电路的同源性的理解。尽管大量证据表明海马-杏仁核回路介导情境恐惧学习，但先前的研究表明，该通路在灵长类动物中比在啮齿类动物中受到更多限制。此外，杏仁核的细胞成分因物种而异。杏仁核的旁层核（PL）是一个与基底核密切相关的结构，在啮齿类动物中没有明确的同源物。在人类和非人类灵长类动物中，PL 都包含未成熟神经元的亚群，这些神经元合并到皮质杏仁样过渡区 (CTA)。为了了解未成熟神经元是否参与恐惧回路，我们首先绘制了猴子的海马-杏仁核投影。然后我们确定未成熟的神经元是否是这条路径的目标。逆行结果表明，海马对杏仁核的输入起源于钩回区（CA1'）和吻侧前唇，这与早期的研究一致。杏仁核海马区、腹侧基底核、内侧旁层核及其与 CTA 的汇合处是该投影的主要目标。未成熟神经元在 PL 和皮质杏仁样过渡区 (CTA) 中很突出，并且与 CA1' 的顺行标记纤维重叠，特别是在内侧 PL 和 CTA 中。与啮齿类动物相比，海马对杏仁核的输入更集中于高等灵长类动物，这支持了之前的解剖学研究和最近来自情境恐惧的人类功能成像研究的数据。在细胞水平上，海马与杏仁核中未成熟神经元的相互作用表明细胞可塑性的新基质，对情境学习和情绪记忆过程的机制具有影响。
Elucidation of the ‘fear circuit’ has opened exciting avenues for understanding and treating human anxiety disorders. However, the translation of rodent to human studies, and vice versa, depends on understanding the homology in relevant circuits across species. Although abundant evidence indicates that the hippocampal-amygdala circuit mediates contextual fear learning, previous studies indicate that this pathway is more restricted in the primate than in rodent. Moreover, cellular components of the amygdala differ across species. The paralaminar nucleus (PL) of the amygdala, a structure that is closely associated with the basal nucleus, is one example, having no clear homologue in rodents. In both human and nonhuman primates, the PL contains a subpopulation of immature-appearing neurons, which merge into the corticoamygdaloid transition area (CTA). To understand whether immature-appearing neurons are positioned to participate in fear circuitry, we first mapped the hippocampal-amygdala projection in the monkey. We then determined whether immature appearing neurons were targets of this path. Retrograde results show that the hippocampal inputs to the amygdala originate in uncal region (CA1’) and the rostral prosubiculum, consistent with earlier studies. The amygdalohippocampal area, ventral basal nucleus, the medial paralaminar nucleus, and its confluence with the CTA are the main targets of this projection. Immature neurons are prominent in the PL and corticoamygdaloid transition area (CTA), and are overlapped by anterogradely labeled fibers from CA1’, particularly in the medial PL and CTA. Hippocampal inputs to the amygdala are more focused in higher primates compared to rodents, supporting previous anatomic studies and recent data from human functional imaging studies of contextual fear. At the cellular level, a hippocampal interaction with immature neurons in the amygdala suggests a novel substrate for cellular plasticity, with implications for mechanisms underlying contextual learning and emotional memory processes.
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