Near-infrared light-responsive MnOx/Ag3PO4 heterojunction for rapidly eradicating sternal fracture implant infection
Near-infrared light-responsive MnOx/Ag3PO4 heterojunction for rapidly eradicating sternal fracture implant infection
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近红外光响应 MnOx/Ag3PO4 异质结可快速消除胸骨骨折植入物感染
DOI：
10.1016/j.colcom.2022.100679
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发表时间：
2022-11
影响因子：
4.5
通讯作者：
Zhaoyang Li
中科院分区：
文献类型：
--
作者：
Yifan Wang;Yingde Xu;Honggang Xia;Hao Gong;Dongbin Wang;Shengli Zhu;Yanqin Liang;Shuilin Wu;Zhaoyang Li
在开放性种植手术中，细菌感染通常会导致手术失败并使患者痛苦。在此，近红外光响应MnOx/Ag 3 PO 4异质结被设计用于快速根除胸骨骨折植入物感染。分别采用一步低温水热法、离子交换法和静电吸附法在Ti基体上制备了MnOx和Ag 3 PO 4涂层。值得注意的是，MnOx/Ag 3 PO 4异质界面的内电场促进了光生电子的迁移.相应地，该异质结在808 nm近红外光照射15 min后，对金黄色葡萄球菌（抑菌率为99.5%）和大肠杆菌（抑菌率为98.8%）可产生丰富的活性氧和局部热（约53 °C）。体内实验也证实了胸骨骨折植入物上的混合涂层具有良好的生物安全性，并有效地根除了细菌感染。这一策略可能为开放手术中的光响应抗菌植入物提供新的见解。MnOx/Ag 3 PO 4异质界面的内电场能促进光生电子的迁移。MnOx/Ag 3 PO 4异质结在808 nm近红外波段具有显著的光动力治疗和光热效应。·MnOx/Ag 3 PO 4涂层对胸骨骨折植入物的金黄色葡萄球菌有较好的抗菌效果。
Bacterial infection in open implant surgery usually causes surgery failure and afflicts patient. Herein, a near-infrared light-responsive MnO x /Ag 3 PO 4 heterojunction is designed for rapidly eradicating sternal fracture implant infection. Specifically, MnO x and Ag 3 PO 4 coatings on Ti substrate are prepared by one-step low-temperature hydrothermal method and ion exchange and electrostatic adsorption methods, respectively. Notably, the internal electric field in the MnO x /Ag 3 PO 4 heterointerface facilitates the migration of photogenerated electrons. Correspondingly, this heterojunction can produce abundant reactive oxygen species and local heat (∼53 °C) against Staphylococcus aureus (antibacterial rate is 99.5%) and Escherichia coli (antibacterial rate is 98.8%) for 15 min 808 nm NIR light irradiation. The in vivo experiment also confirmed the hybrid coating on sternal fracture implant exhibits good biosafety and effectively eradicates bacterial infection. This strategy may provide new insight into light-responsive antibacterial implant in open surgery. • The internal electric field in the MnO x /Ag 3 PO 4 heterointerface can facilitate the migration of photogenerated electrons. • MnO x /Ag 3 PO 4 heterojunction has outstanding photodynamic therapeutic and photothermal effects under 808 nm NIR. • MnO x /Ag 3 PO 4 coating on sternal fracture implant has high antibacterial efficacy against Staphylococcus aureus .
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影响因子：
16.6
作者：
Raja A;Chaves A;Yu J;Arefe G;Hill HM;Rigosi AF;Berkelbach TC;Nagler P;Schüller C;Korn T;Nuckolls C;Hone J;Brus LE;Heinz TF;Reichman DR;Chernikov A
通讯作者：
Chernikov A
影响因子：
4.5
作者：
Jianghong Luo;Bakri Mamat;Z. Yue;Naiyin Zhang;Xiaojun Xu;Yunling Li;Z. Su;Chuang Ma;Fazhi Zang;Yingbo Wang
通讯作者：
Jianghong Luo;Bakri Mamat;Z. Yue;Naiyin Zhang;Xiaojun Xu;Yunling Li;Z. Su;Chuang Ma;Fazhi Zang;Yingbo Wang
影响因子：
4.5
作者：
Shuting Wang;Yu Fang;Zequn Zhang;Qiao Jin-;J. Ji
通讯作者：
Shuting Wang;Yu Fang;Zequn Zhang;Qiao Jin-;J. Ji
影响因子：
9.5
作者：
Xianzhou Xie;Congyang Mao;Xiangmei Liu;Yanzhe Zhang;Z. Cui;Xian-Jin Yang;K. Yeung;H. Pan;P. C
通讯作者：
Xianzhou Xie;Congyang Mao;Xiangmei Liu;Yanzhe Zhang;Z. Cui;Xian-Jin Yang;K. Yeung;H. Pan;P. C
DOI：
10.1016/j.jmst.2022.06.005
发表时间：
2022-06
期刊：
Journal of Materials Science & Technology
影响因子：
--
作者：
Yuancheng Lin;Haixin Zhang;Yiguo Zou;Kunyan Lu;Luohuizi Li;Yan Wu;Jingjing Cheng;Yanxia Zhang;Hong Chen;Qian Yu
通讯作者：
Yuancheng Lin;Haixin Zhang;Yiguo Zou;Kunyan Lu;Luohuizi Li;Yan Wu;Jingjing Cheng;Yanxia Zhang;Hong Chen;Qian Yu