Transplantation-mediated strategies to promote axonal regeneration following spinal cord injury.
Transplantation-mediated strategies to promote axonal regeneration following spinal cord injury.
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DOI：
10.1016/j.resp.2009.07.016
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发表时间：
2009-11-30
影响因子：
2.3
通讯作者：
Onifer, Stephen M.
中科院分区：
文献类型：
--
作者：
Xu, Xiao-Ming;Onifer, Stephen M.
破坏性的中枢神经系统损伤和疾病继续发生，尽管各种预防计划的巨大努力。由于它们造成的医疗费用的逐年增加和不可避免性，需要负责任地制定治疗策略。损伤和疾病后发生的功能障碍主要是由于神经传递损伤。过去二十年的实验和临床研究表明，神经和非神经组织和细胞移植是改善功能障碍以显着改善生活质量的可行选择。此外，组织和细胞移植在病理生理学、可塑性、发芽、再生和功能恢复方面的研究也取得了重大进展。本章将回顾有关的能力和潜力，特别是创伤性脊髓损伤，神经和非神经组织和细胞移植，以取代失去的神经元和胶质细胞，重建受损的神经回路，并恢复神经递质，激素，神经营养因子和神经传递的信息。将要讨论的供体组织和细胞包括外周神经、胎儿脊髓和脑、中枢和外周神经系统的胶质细胞、干细胞、那些经过基因工程改造的细胞和非神经细胞。组合方法和临床研究也进行了审查。
Devastating central nervous system injuries and diseases continue to occur in spite of the tremendous efforts of various prevention programs. The enormity of and annual escalation of healthcare costs due to them require that therapeutic strategies be responsibly developed. The dysfunctions that occur after injury and disease are primarily due to neurotransmission damage. The last two decades of both experimental and clinical research have demonstrated that neural and non-neural tissue and cell transplantation is a viable option for ameliorating dysfunctions to markedly improve quality of life. Moreover, significant progress has been made with tissue and cell transplantation in studies of pathophysiology, plasticity, sprouting, regeneration, and functional recovery. This chapter will review information about the ability and potential, particularly for traumatic spinal cord injury, that neural and non-neural tissue and cell transplantation has to replace lost neurons and glia, reconstruct damaged neural circuitry, and to restore neurotransmitters, hormones, neurotrophic factors, and neurotransmission. Donor tissues and cells to be discussed include peripheral nerve, fetal spinal cord and brain, central and peripheral nervous systems’ glia, stem cells, those that have been genetically engineered, and non-neural ones. Combinatorial approaches and clinical research are also reviewed.
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