Hierarchical Inflammatory Phenotypes of Depression: A Novel Approach Across Five Independent Samples and 27,730 Adults.
Hierarchical Inflammatory Phenotypes of Depression: A Novel Approach Across Five Independent Samples and 27,730 Adults.
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抑郁症的分层炎症表型：五个独立样本和27,730名成年人的新方法。
DOI：
10.1016/j.biopsych.2022.08.017
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发表时间：
2023-02-01
影响因子：
10.6
通讯作者：
中科院分区：
文献类型：
--
作者：
虽然表征炎症和抑郁症之间的关联可能对告知理论，研究和治疗决策至关重要，但现有的研究受到了限制，因为忽略了炎症可能同时与广泛的抑郁症和症状子集相关。这种缺乏直接比较的情况阻碍了人们对抑郁症炎症表型的理解，也严重忽视了炎症可能与抑郁症广泛和个体症状的独特相关性。我们在5个NHANES（国家健康和营养检查调查）队列（N = 27，730，51%女性，平均年龄= 46岁）中使用了适度非线性因素分析。C-反应蛋白（CRP）同时与潜在的抑郁，食欲和疲劳有关。具体而言，CRP与所有5个样本中的潜伏性抑郁症相关（rs：0.044 - 0.089; ps：<.001-.002），并与食欲和（显著rs：0.031 - 0.049，显著ps：0.001 - 0.007）和疲劳（显著rs：0.030 - 0.054，显著ps：<0.001 - 0.029）。这些结果对于协变量基本上是稳健的。在方法学上，这些模型指示患者健康问卷-9作为CRP的函数是标量非不变的（即，相同的患者健康调查问卷-9评分可以代表具有高与低CRP水平的患者中的不同结构）。因此，如果不考虑抑郁症特异性相关性，抑郁症总分和CRP的平均值比较可能会产生误导。从概念上讲，这些发现表明，研究抑郁症的炎症表型的研究应该研究炎症如何同时与抑郁症广泛和特定症状相关，以及这些关系是否通过不同的机制发挥作用。这有可能产生新的理论见解，并可能导致开发新的治疗方法来减少炎症相关的抑郁症症状。
Although characterizing associations between inflammation and depression may prove critical for informing theory, research, and treatment decisions, extant research has been limited by ignoring the possibility that inflammation may be simultaneously associated with depression broadly and with a subset of symptoms. This lack of direct comparison has hampered attempts to understand inflammatory phenotypes of depression and critically fails to consider that inflammation might be uniquely associated with both depression broadly and individual symptoms. We used moderated nonlinear factor analysis in 5 NHANES (National Health and Nutrition Examination Survey) cohorts (N = 27,730, 51% female, mean age = 46 years). C-reactive protein (CRP) is simultaneously associated with latent depression, appetite, and fatigue. Specifically, CRP was associated with latent depression in all 5 samples (rs: 0.044–0.089; ps: < .001–.002) and was associated with both appetite (significant rs: 0.031–0.049, significant ps: .001–.007) and fatigue (significant rs: 0.030–0.054, significant ps: < .001–.029) in 4 samples. These results were largely robust to covariates. Methodologically, these models indicate that the Patient Health Questionnaire-9 is scalar non-invariant as a function of CRP (i.e., identical Patient Health Questionnaire-9 scores may represent different constructs in those with high vs. low CRP levels). Therefore, mean comparisons of depression total scores and CRP might be misleading without accounting for symptom-specific associations. Conceptually, these findings indicate that studies investigating inflammatory phenotypes of depression should examine how inflammation is simultaneously related both to depression broadly and to specific symptoms, and whether these relations function via different mechanisms. This has the potential to yield new theoretical insights and may lead to the development of novel therapies for reducing inflammation-related symptoms of depression.
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DOI：
10.1016/j.bbih.2021.100288
发表时间：
2021-10
期刊：
Brain, behavior, & immunity - health
影响因子：
--
作者：
Moriarity DP
通讯作者：
Moriarity DP
炎症在抑郁症的核心特征中的作用：使用外源引起的炎症从范式发出的见解。
影响因子：
8.2
作者：
Dooley LN;Kuhlman KR;Robles TF;Eisenberger NI;Craske MG;Bower JE
通讯作者：
Bower JE
DOI：
10.1080/10705511.2017.1402334
发表时间：
2018
期刊：
Structural equation modeling : a multidisciplinary journal
影响因子：
--
作者：
Hallquist MN;Wiley JF
通讯作者：
Wiley JF
影响因子：
4.2
作者：
Duivis, Hester E.;Kupper, Nina;de Jonge, Peter
通讯作者：
de Jonge, Peter
影响因子：
7.7
作者：
Gilman, SE;Kawachi, I;Buka, SL
通讯作者：
Buka, SL