Building a replicable and clinically-impactful immunopsychiatry: Methods, phenotyping, and theory integration.

Building a replicable and clinically-impactful immunopsychiatry: Methods, phenotyping, and theory integration.
复制标题

DOI:
10.1016/j.bbih.2021.100288
复制
发表时间:
2021-10
期刊:
Brain, behavior, & immunity - health
影响因子:
--
通讯作者:
Moriarity DP
Moriarity DP
中科院分区:
其他
文献类型:
--
作者:
Moriarity DP

文献摘要

参考文献

被引文献

相似文献

免疫精神病学是精神神经免疫学的一个分支,它整合了免疫学和精神病理学的过程,并有望改善精神病理学的分类、鉴定和治疗。以炎症和抑郁症之间关系的研究为例,这篇小型综述将讨论未来研究中应强调的三个工作领域,以最大限度地提高该领域的可复制性和临床影响:1)关于计划数据收集和统计分析的方法,考虑到测量特性和概念上重要的方差来源,2)表征精神病理学的炎症表型,以及3)将炎症过程整合到精神病理学风险的稳健的、现存的心理社会理论框架中。这三个领域的一致、平行增长将确保免疫精神病学研究是可复制的,有助于理解免疫系统如何(以及对谁)与精神症状相关,并增加个性化治疗计划的灵活性和力量。
Immunopsychiatry is a subfield of psychoneuroimmunology that integrates immunological and psychopathological processes with promise for improving the classification, identification, and treatment of psychopathology. Using research on the relationship between inflammation and depression as a running example, this mini-review will discuss three areas of work that should be emphasized in future research to maximize the replicability and clinical impact of the field: 1) methodology with respect to planning data collection and statistical analyses with measurement properties and conceptually important sources of variance in mind, 2) characterizing inflammatory phenotypes of psychopathology, and 3) the integration of inflammatory processes into robust, extant psychosocial theoretical frameworks of psychopathology risk. Consistent, parallel growth in all three areas will ensure immunopsychiatry research is replicable, contributes to understanding of how (and for whom) the immune system is associated with psychiatric symptoms, and increases the flexibility and power of personalized treatment planning.
炎症在抑郁症的核心特征中的作用:使用外源引起的炎症从范式发出的见解。
DOI: 10.1016/j.neubiorev.2018.09.006
发表时间: 2018-11
影响因子: 8.2
作者:
Dooley LN;Kuhlman KR;Robles TF;Eisenberger NI;Craske MG;Bower JE
通讯作者: Bower JE
DOI: 10.1038/tp.2017.76
发表时间: 2017-05-16
影响因子: 6.8
作者:
Euteneuer F;Dannehl K;Del Rey A;Engler H;Schedlowski M;Rief W
通讯作者: Rief W
DOI: 10.1016/j.psyneuen.2005.04.008
发表时间: 2005-11-01
影响因子: 3.7
作者:
Brosschot, JF;Pieper, S;Thayer, JF
通讯作者: Thayer, JF
DOI: 10.1016/s0889-1591(02)00007-7
发表时间: 2002-10-01
影响因子: 15.1
作者:
Capuron, L;Hauser, P;Neveu, PJ
通讯作者: Neveu, PJ
DOI: 10.1016/s0306-4530(01)00030-0
发表时间: 2001-11-01
影响因子: 3.7
作者:
Capuron, L;Ravaud, A;Neveu, PJ
通讯作者: Neveu, PJ