Parvalbumin(+) interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus.
Parvalbumin(+) interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus.
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DOI：
10.1038/s41467-018-06899-3
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发表时间：
2018-11-02
影响因子：
16.6
通讯作者：
Jonas P
中科院分区：
文献类型：
--
作者：
Espinoza C;Guzman SJ;Zhang X;Jonas P
海马微回路中的小清蛋白阳性（PV+）GABA能中间神经元被认为在几种高级网络功能中发挥关键作用，例如前馈和反馈抑制、网络振荡和模式分离。GABA能中间神经元介导的快速侧抑制可能在海马输入层实现赢家通吃机制。然而，目前还不清楚是否在齿状回的颗粒细胞（GC）和中间神经元的功能连接规则是符合这样一个机制。使用同时膜片钳记录从多达7个GC和多达4个PV+ interneurons在齿状回，我们发现，连接结构的空间，突触特异性，并丰富了特定的双突触图案。与新皮层相反，齿状回中的侧向抑制（其中GC通过PV+中间神经元抑制邻近的GC）比复发性抑制（其中GC抑制自身）丰富约10倍。因此，独特的连接规则可以使齿状回执行特定的高阶计算。已知GABA能中间神经元提供抑制以允许神经元网络的计算功能。在这里，Espinoza及其同事表明，小鼠海马齿状回中颗粒细胞和中间神经元的连接性与能够执行赢家通吃机制的电路结构一致。
Parvalbumin-positive (PV+) GABAergic interneurons in hippocampal microcircuits are thought to play a key role in several higher network functions, such as feedforward and feedback inhibition, network oscillations, and pattern separation. Fast lateral inhibition mediated by GABAergic interneurons may implement a winner-takes-all mechanism in the hippocampal input layer. However, it is not clear whether the functional connectivity rules of granule cells (GCs) and interneurons in the dentate gyrus are consistent with such a mechanism. Using simultaneous patch-clamp recordings from up to seven GCs and up to four PV+ interneurons in the dentate gyrus, we find that connectivity is structured in space, synapse-specific, and enriched in specific disynaptic motifs. In contrast to the neocortex, lateral inhibition in the dentate gyrus (in which a GC inhibits neighboring GCs via a PV+ interneuron) is ~ 10-times more abundant than recurrent inhibition (in which a GC inhibits itself). Thus, unique connectivity rules may enable the dentate gyrus to perform specific higher-order computations. GABAergic interneurons are known to provide inhibition to allow computational function of neuronal network. Here, Espinoza and colleagues show that connectivity of granule cells and interneurons in the dentate gyrus of mouse hippocampus are consistent with the circuit architecture capable of performing a winners-take-all mechanism.
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DOI：
10.1523/jneurosci.6044-08.2009
发表时间：
2009-06-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
de Almeida L;Idiart M;Lisman JE
通讯作者：
Lisman JE
影响因子：
16.2
作者：
Danielson NB;Turi GF;Ladow M;Chavlis S;Petrantonakis PC;Poirazi P;Losonczy A
通讯作者：
Losonczy A
影响因子：
56.9
作者：
Galarreta, M;Hestrin, S
通讯作者：
Hestrin, S
影响因子：
16.2
作者：
Geiger, JRP;Lubke, J;Jonas, P
通讯作者：
Jonas, P
影响因子：
16.6
作者：
Cayco-Gajic NA;Clopath C;Silver RA
通讯作者：
Silver RA