Sex differences in translocator protein 18 kDa (TSPO) in the heart: implications for imaging myocardial inflammation.
Sex differences in translocator protein 18 kDa (TSPO) in the heart: implications for imaging myocardial inflammation.
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DOI：
10.1007/s12265-013-9538-0
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发表时间：
2014-03
影响因子：
3.4
通讯作者：
Guilarte, Tomas R.
中科院分区：
文献类型：
--
作者：
Fairweather, DeLisa;Coronado, Michael J.;Garton, Amanda E.;Dziedzic, Jennifer L.;Bucek, Adriana;Cooper, Leslie T., Jr.;Brandt, Jessica E.;Alikhan, Fatima S.;Wang, Haofan;Endres, Christopher J.;Choi, Judy;Pomper, Martin G.;Guilarte, Tomas R.
男性心肌炎比女性更严重，由于缺乏直接检测心肌炎的成像手段，因此很难诊断。移位器蛋白18 kDa(TSPO)由于存在于CD11b+脑小胶质细胞中，被广泛用于脑部炎症的成像。在这项研究中，我们检测了柯萨奇病毒B3(CVB3)心肌炎小鼠和心肌炎患者的活检组织中TSPO和CD11b的表达，以确定其是否可以用于心肌炎的成像。我们发现，患有CVB3心肌炎的雄性小鼠比雌性小鼠上调了更多与TSPO激活相关的基因。与雌性相比，雄性小鼠和患有心肌炎的雄性小鼠心脏中TSPO的表达由于睾酮的作用而增加，TSPO主要在CD11b+免疫细胞中表达。我们发现，TSPO配体使用microSPECT检测心肌炎症，与未患病的对照组相比，患有CVB3心肌炎的雄性小鼠对[125I]-IodDPA-713的摄取增加。
Myocarditis is more severe in men than women and difficult to diagnose due to a lack of imaging modalities that directly detect myocardial inflammation. Translocator protein 18 kDa (TSPO) is used extensively to image brain inflammation due to its presence in CD11b+ brain microglia. In this study we examined expression of TSPO and CD11b in mice with coxsackievirus B3 (CVB3) myocarditis and biopsy sections from myocarditis patients in order to determine if it could be used to image myocarditis. We found that male mice with CVB3 myocarditis upregulated more genes associated with TSPO activation than females. TSPO expression was increased in the heart of male mice and men with myocarditis compared to females due to testosterone, where it was expressed predominantly in CD11b+ immune cells. We show that TSPO ligands detect myocardial inflammation using microSPECT, with increased uptake of [125I]-IodoDPA-713 in male mice with CVB3 myocarditis compared to undiseased controls.
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影响因子：
4.1
作者：
Batarseh, Amani;Papadopoulos, Vassilios
通讯作者：
Papadopoulos, Vassilios
影响因子：
15.1
作者：
Frisancho-Kiss, Sylvia;Coronado, Michael J.;Frisancho, J. Augusto;Lau, Vivian M.;Rose, Noel R.;Klein, Sabra L.;Fairweather, DeLisa
通讯作者：
Fairweather, DeLisa
影响因子：
6.2
作者：
Choi, Judy;Ifuku, Masataka;Noda, Mami;Guilarte, Tomas R.
通讯作者：
Guilarte, Tomas R.
影响因子：
39.3
作者：
Gaemperli, Oliver;Shalhoub, Joseph;Camici, Paolo G.
通讯作者：
Camici, Paolo G.
DOI：
10.1056/nejmra0800028
发表时间：
2009-04-09
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cooper LT Jr
通讯作者：
Cooper LT Jr