Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states.
Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states.
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DOI：
10.1016/j.mce.2010.06.013
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发表时间：
2010-10-07
影响因子：
4.1
通讯作者：
Papadopoulos, Vassilios
中科院分区：
文献类型：
--
作者：
Batarseh, Amani;Papadopoulos, Vassilios
关键词：
易位蛋白 (TSPO) 是一种 18 kDa 高亲和力胆固醇和药物结合蛋白，主要存在于线粒体外膜中。尽管 TSPO 存在于许多组织类型中，但在正常条件下，它在合成类固醇的组织中表达水平最高。 TSPO 与胆固醇输入线粒体有关，这是类固醇生成的关键功能，并且直接或间接与多种其他细胞功能相关，包括细胞凋亡、细胞增殖、分化、阴离子转运、卟啉转运、血红素合成和线粒体功能调节。 TSPO 的异常表达与多种疾病有关，包括癌症、脑损伤、神经退行性变和缺血再灌注损伤。在过去的十年中，人们一直致力于了解调节组织和疾病特异性 TSPO 表达的机制，并确定控制其表达的药理学方法。本综述重点关注在生理条件下以组织和疾病特异性方式调节 Tspo 基因表达的化学物质、激素和分子机制的当前知识。这里描述的结果提供了证据，证明 PKCε-ERK1/2-AP1/Stat3 信号转导途径是表达高水平 TSPO 的正常和病理组织中 Tspo 基因表达的主要调节因子。
Translocator protein (TSPO) is an 18-kDa high affinity cholesterol- and drug-binding protein found primarily in the outer mitochondrial membrane. Although TSPO is found in many tissue types, it is expressed at the highest levels under normal conditions in tissues that synthesize steroids. TSPO has been associated with cholesterol import into mitochondria, a key function in steroidogenesis, and directly or indirectly with multiple other cellular functions including apoptosis, cell proliferation, differentiation, anion transport, porphyrin transport, heme synthesis, and regulation of mitochondrial function. Aberrant expression of TSPO has been linked to multiple diseases, including cancer, brain injury, neurodegeneration, and ischemia reperfusion injury. There has been an effort during the last decade to understand the mechanisms regulating tissue- and disease-specific TSPO expression and to identify pharmacological means to control its expression. This review focuses on the current knowledge regarding the chemicals, hormones, and molecular mechanisms regulating Tspo gene expression under physiological conditions in a tissue- and disease-specific manner. The results described here provide evidence that the PKCε-ERK1/2-AP1/Stat3 signal transduction pathway is the primary regulator of Tspo gene expression in normal and pathological tissues expressing high levels of TSPO.
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影响因子：
6.1
作者：
BARAMI, S;AMIRI, Z;GAVISH, M
通讯作者：
GAVISH, M
影响因子：
15.9
作者：
Bromberg, J
通讯作者：
Bromberg, J
影响因子：
3.9
作者：
Budas, G. R.;Mochly-Rosen, D.
通讯作者：
Mochly-Rosen, D.
影响因子：
4.8
作者：
Amri, H;Ogwuegbu, SO;Papadopoulos, V
通讯作者：
Papadopoulos, V
影响因子：
2.9
作者：
Batarseh A;Li J;Papadopoulos V
通讯作者：
Papadopoulos V