Micro and Nano Material Carriers for Immunomodulation.
Micro and Nano Material Carriers for Immunomodulation.
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DOI：
10.1111/ajt.13878
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Keselowsky BG
中科院分区：
文献类型：
--
作者：
Bracho-Sanchez E;Xia CQ;Clare-Salzler MJ;Keselowsky BG
Modulation of the immune system through the use of micro and nano carriers offers opportunities in transplant tolerance, autoimmunity, infectious disease and cancer. In particular, polymeric, lipid and inorganic materials have been used as carriers of proteins, nucleic acids, and small drug molecules to direct the immune system toward either suppressive or stimulatory states. Current technologies have focused on the use of particulates or scaffolds, the modulation of materials properties, and the delivery of biologics or small drug molecules to achieve a desired response. Discussed are relevant immunology concepts, the types of biomaterial-carriers used for immunomodulation highlighting their benefits and drawbacks, the material properties influencing immune responses, and recent examples in the field of transplant tolerance.
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