Impact of Uterine Adenomyosis on Pregnancy Outcomes in Women Undergoing In Vitro Fertilization Treated With a Long-Term Pituitary Downregulation Protocol.
Impact of Uterine Adenomyosis on Pregnancy Outcomes in Women Undergoing In Vitro Fertilization Treated With a Long-Term Pituitary Downregulation Protocol.
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子宫腺肌病对接受长期垂体下调方案治疗的体外受精女性妊娠结局的影响
DOI：
10.3389/fendo.2021.655803
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发表时间：
2021
影响因子：
5.2
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Zhang J;Hu L;Bu Z;Sun Y
有研究表明子宫腺肌病患者的妊娠结局与正常子宫妇女相当，但目前尚无一致结论。我们招募了65名子宫腺肌病患者和260名频率匹配的子宫内膜异位症对照妇女，根据年龄比例为1：4。在控制其他因素后，比较两组的临床妊娠率、自然流产率和活产率。子宫腺肌病患者窦卵泡数（AFC）高于子宫内膜异位症患者（12.71 vs 11.65，P=0.027）。两组移植胚胎数相同，但子宫腺肌病患者的种植率明显下降（31.91%vs46.74%，P =0.005），临床妊娠率（47.06%vs64.42%，P =0.028），活产率（31.37%vs54.81%，P =0.004），自然流产率明显增加（33.33%vs13.43%，P =0.034）。多因素Logistic回归分析显示，在控制年龄和胚胎移植次数的情况下，子宫腺肌病对妊娠结局有不利影响（调整OR=0.361，P=0.003）。即使在与年龄相匹配后，子宫腺肌病仍对接受长方案IVF的患者的妊娠结局产生不利影响。
Some studies have demonstrated that adenomyosis patients can achieve a comparable pregnancy outcome with women with normal uteruses, while there is no unanimous conclusion at present. We recruited 65 adenomyosis patients and 260 frequency-matched control women with endometriosis at a ratio of 1:4 according to age. Clinical pregnancy rate, spontaneous abortion rate, and live birth rate were compared between these two groups after controlling other factors. Compared with endometriosis patients, adenomyosis patients had a higher antral follicle count (AFC) (12.71 vs 11.65, P=0.027). Though the two groups had the same number of embryos transferred, adenomyosis patients had an obviously declined implantation rate (31.91% vs 46.74%, P=0.005), clinical pregnancy rate (47.06% vs 64.42%, P=0.028), live birth rate (31.37% vs 54.81%, P=0.004), and significantly increased spontaneous abortion rate (33.33% vs 13.43%, P=0.034). Multivariate logistic regression analysis showed that adenomyosis had adverse influences on pregnancy outcome when age and the number of embryo transfers were controlled (adjusted OR=0.361, P=0.003). Even after being matched with age, adenomyosis still had adverse influences on the pregnancy outcome of IVF in patients undergoing the long protocol.
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影响因子：
4
作者：
Li, Xiaoxue;Pan, Ningning;Ma, Caihong
通讯作者：
Ma, Caihong
DOI：
10.1016/j.ejogrb.2010.02.047
发表时间：
2010-07-01
影响因子：
2.6
作者：
Mijatovic, V.;Florijn, E.;Hompes, P.
通讯作者：
Hompes, P.
影响因子：
--
作者：
Agarwal SK;Daniels A;Drosman SR;Udoff L;Foster WG;Pike MC;Spicer DV;Daniels JR
通讯作者：
Daniels JR
DOI：
10.1016/j.ejogrb.2011.04.030
发表时间：
2011-10-01
影响因子：
2.6
作者：
Costello, Michael F.;Lindsay, Kristen;McNally, Glen
通讯作者：
McNally, Glen
影响因子：
3.1
作者：
Fritz, Rani;Jindal, Sangita;Buyuk, Erkan
通讯作者：
Buyuk, Erkan