Coronary heart disease and risk for cognitive impairment or dementia: Systematic review and meta-analysis.
Coronary heart disease and risk for cognitive impairment or dementia: Systematic review and meta-analysis.
复制标题
DOI：
10.1371/journal.pone.0184244
复制
发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Köhler S
中科院分区：
文献类型：
--
作者：
Deckers K;Schievink SHJ;Rodriquez MMF;van Oostenbrugge RJ;van Boxtel MPJ;Verhey FRJ;Köhler S
越来越多的证据表明，冠心病与认知障碍或痴呆症的风险之间存在关联，但没有研究系统地回顾这种关联。因此，我们总结了冠心病与认知障碍或痴呆风险之间关系的现有证据。检索了Medline、Embase、PsycINFO和CINAHL中截至2016年1月8日的所有出版物。符合纳入标准的文献纳入：（1）心肌梗死、心绞痛或冠心病（两者的组合）作为预测变量;（2）认知、认知障碍或痴呆作为结局;（3）基于人群的研究;（4）前瞻性（≥1年随访）、横断面或病例对照研究设计;（5）≥100例受试者;（6）年龄≥45岁。手动检索出版物和二次文献的参考文献列表，以查找可能缺失的文章。两名评审员独立筛选所有摘要，并使用标准化数据收集表从潜在相关全文文章中提取信息。研究质量采用Newcastle-Ottawa量表进行评估。我们使用随机效应荟萃分析从最充分调整的模型中汇总了估计值。我们确定了6，132篇摘要，其中24篇研究被纳入。对10项前瞻性队列研究的荟萃分析显示，冠心病与认知功能障碍或痴呆的风险增加有关（OR = 1.45，95%CI = 1.21-1.74，p<0.001）。研究间异质性较低（I2 = 25.7%，95%CI = 0-64，p = 0.207）。在前瞻性队列研究的单独荟萃分析中，也发现了类似的显著相关性，用于个体预测因素（心肌梗死、心绞痛）。相反，横断面和病例对照研究的荟萃分析是不确定的。这项荟萃分析表明，冠心病与认知功能障碍或痴呆的发生率增加具有前瞻性相关性。鉴于预计全球范围内受冠心病和痴呆症影响的人数将增加，因此需要深入了解心脑联系的因果机制或共同途径。
Accumulating evidence suggests an association between coronary heart disease and risk for cognitive impairment or dementia, but no study has systematically reviewed this association. Therefore, we summarized the available evidence on the association between coronary heart disease and risk for cognitive impairment or dementia. Medline, Embase, PsycINFO, and CINAHL were searched for all publications until 8th January 2016. Articles were included if they fulfilled the inclusion criteria: (1) myocardial infarction, angina pectoris or coronary heart disease (combination of both) as predictor variable; (2) cognition, cognitive impairment or dementia as outcome; (3) population-based study; (4) prospective (≥1 year follow-up), cross-sectional or case-control study design; (5) ≥100 participants; and (6) aged ≥45 years. Reference lists of publications and secondary literature were hand-searched for possible missing articles. Two reviewers independently screened all abstracts and extracted information from potential relevant full-text articles using a standardized data collection form. Study quality was assessed with the Newcastle-Ottawa Scale. We pooled estimates from the most fully adjusted model using random-effects meta-analysis. We identified 6,132 abstracts, of which 24 studies were included. A meta-analysis of 10 prospective cohort studies showed that coronary heart disease was associated with increased risk of cognitive impairment or dementia (OR = 1.45, 95%CI = 1.21–1.74, p<0.001). Between-study heterogeneity was low (I2 = 25.7%, 95%CI = 0–64, p = 0.207). Similar significant associations were found in separate meta-analyses of prospective cohort studies for the individual predictors (myocardial infarction, angina pectoris). In contrast, meta-analyses of cross-sectional and case-control studies were inconclusive. This meta-analysis suggests that coronary heart disease is prospectively associated with increased odds of developing cognitive impairment or dementia. Given the projected worldwide increase in the number of people affected by coronary heart disease and dementia, insight into causal mechanisms or common pathways underlying the heart-brain connection is needed.
登录
查看更多内容
DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Debette S;Markus HS
通讯作者：
Markus HS
影响因子：
7.2
作者：
Hughes, Tiffany F.;Andel, Ross;Gatz, Margaret
通讯作者：
Gatz, Margaret
影响因子：
5.4
作者：
Haring B;Leng X;Robinson J;Johnson KC;Jackson RD;Beyth R;Wactawski-Wende J;von Ballmoos MW;Goveas JS;Kuller LH;Wassertheil-Smoller S
通讯作者：
Wassertheil-Smoller S
影响因子：
9.9
作者：
ARONSON, MK;OOI, WL;KATZMAN, R
通讯作者：
KATZMAN, R
影响因子：
--
作者：
BRETELER, MMB;CLAUS, JJ;HOFMAN, A
通讯作者：
HOFMAN, A