The Olfactory System: Basic Anatomy and Physiology for General Otorhinolaryngologists.

The Olfactory System: Basic Anatomy and Physiology for General Otorhinolaryngologists.
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DOI:
10.21053/ceo.2023.00185
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发表时间:
2023-11
影响因子:
3
通讯作者:
--
中科院分区:
医学2区
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嗅觉是人类五种基本感觉之一,也是已知的最原始的感觉之一。在史前社会,嗅觉可能对人类的生存至关重要,尽管许多人认为它的重要性随着时间的推移而减弱,但它继续对人类的互动、纽带和物种的繁殖产生影响。即使我们没有意识到,嗅觉也会极大地影响我们的生活,与整体生活质量和健康密切相关。尽管如此,与其他感官相比,从科学的角度来看,嗅觉一直被忽视。然而,自从嗅觉和味觉丧失被认为是严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染的关键症状以来,嗅觉最近受到了极大的关注。对与2019年冠状病毒病(新冠肺炎)相关的嗅觉丧失的研究表明,嗅觉障碍既可以是传导的,也可以是感觉神经的,可能会导致大脑的结构变化。嗅觉训练是治疗嗅觉功能障碍的有效方法,提示神经联系的重组。嗅觉能力的下降也可能会引起人们对神经退行性疾病或精神疾病的怀疑。在这里,我们总结了作为耳鼻喉科医生,我们应该掌握的关于嗅觉以及管理和帮助嗅觉障碍患者的外周和中枢嗅觉通路的基本知识。
Olfaction is one of the five basic human senses, and it is known to be one of the most primitive senses. The sense of olfaction may have been critical for human survival in prehistoric society, and although many believe its importance has diminished over time, it continues to have an impact on human interaction, bonding, and propagation of the species. Even if we are unaware of it, the sense of smell greatly affects our lives and is closely related to overall quality of life and health. Nonetheless, olfaction has been neglected from a scientific perspective compared to other senses. However, olfaction has recently received substantial attention since the loss of smell and taste has been noted as a key symptom of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Studies investigating olfaction loss in association with coronavirus disease 2019 (COVID-19) have revealed that olfactory dysfunction can be both conductive and sensorineural, possibly causing structural changes in the brain. Olfactory training is an effective treatment for olfactory dysfunction, suggesting the reorganization of neural associations. A reduced ability to smell may also alert suspicion for neurodegenerative or psychiatric disorders. Here, we summarize the basic knowledge that we, as otorhinolaryngologists, should have about the sense of smell and the peripheral and central olfactory pathways for managing and helping patients with olfactory dysfunction.
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