Effects of olfactory training on posttraumatic olfactory dysfunction: a systematic review and meta-analysis.
Effects of olfactory training on posttraumatic olfactory dysfunction: a systematic review and meta-analysis.
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DOI：
10.1002/alr.22758
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发表时间：
2021-07
影响因子：
6.4
通讯作者：
Wu D
中科院分区：
文献类型：
--
作者：
Huang T;Wei Y;Wu D
创伤后嗅觉功能障碍是一个临床挑战，由于难治性的特点和有限的治疗选择。嗅觉训练已被证明是有效的嗅觉功能障碍的各种病因。我们汇总了现有的研究，以评估嗅觉训练对创伤后嗅觉功能障碍患者的影响。使用PubMed、Embase、科克伦图书馆和Web of Science进行系统性文献综述，以确定评估嗅觉训练后创伤后嗅觉功能障碍患者嗅觉变化的研究。在最初审查的812篇摘要中，纳入了13篇全文文章。嗅觉训练后的临床显著结果定义为阈值、辨别力和识别力（TDI）评分改善≥6或宾夕法尼亚大学嗅觉识别测试（UPSIT）评分≥4。Meta分析纳入了6项研究，36.31%（95%置信区间[CI]，0.28 - 0.45）的创伤后患者在嗅觉训练后将获得临床显著结果，TDI评分平均增加4.61。嗅觉训练可能是一种很有前途的治疗创伤后嗅觉功能障碍的方式。需要更多高质量的对照研究来阐明嗅觉训练对整体嗅觉表现和嗅觉亚成分的影响。
Posttraumatic olfactory dysfunction is a clinical challenge due to refractory characteristics and limited therapeutic options. Olfactory training has been proved to be effective for olfactory dysfunction with varied etiologies. We pooled existing studies to evaluate the effects of olfactory training in patients with posttraumatic olfactory dysfunction. A systematic literature review using PubMed, Embase, Cochrane Library, and Web of Science was conducted to identify studies assessing olfactory change in patients with posttraumatic olfactory dysfunction after olfactory training. Of the initial 812 abstracts reviewed, 13 full‐text articles were included. Clinically significant results after olfactory training were defined as an improvement of threshold, discrimination, and identification (TDI) score ≥6 or University of Pennsylvania Smell Identification Test (UPSIT) score ≥4. Six studies were included in the meta‐analysis, 36.31% (95% confidence interval [CI], 0.28 to 0.45) of posttraumatic patients would achieve clinically significant results after olfactory training with a mean increase of TDI score of 4.61. Olfactory training might be a promising modality for the treatment of posttraumatic olfactory dysfunction. More high‐quality studies with controls are needed to clarify the effect of olfactory training on total olfactory performance and subcomponents of olfaction.
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