Effects of Olfactory Training in Patients With Postinfectious Olfactory Dysfunction.
Effects of Olfactory Training in Patients With Postinfectious Olfactory Dysfunction.
复制标题
嗅觉训练对感染后嗅觉障碍患者的影响。
DOI：
10.21053/ceo.2020.00143
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发表时间：
2021-03
影响因子：
3
通讯作者：
Kim JK
中科院分区：
文献类型：
--
作者：
Choi BY;Jeong H;Noh H;Park JY;Cho JH;Kim JK
感染后嗅觉功能障碍（PIOD）是嗅觉功能障碍最常见的病因，嗅觉训练（OT）是 PIOD 公认的治疗方式。一些研究调查了韩国患者的 OT，但其中涉及韩国人不熟悉的气味或没有对照组。本研究的目的是验证 OT 对 PIOD 患者的疗效，使用韩国人熟悉的气味剂并包括对照组。在为期 3 年的研究期间，我们总共招募了 104 名韩国 PIOD 患者。所有参与者在基线评估时和 OT 后 3 个月均使用内窥镜检查和嗅觉功能测试进行评估。嗅觉功能测试使用韩国版嗅探棒（KVSS）II进行。使用视觉模拟量表和简易精神状态检查来评估鼻功能和心理功能。 OT 进行了 3 个月，使用五种气味剂（玫瑰、柠檬、肉桂、橙子和桃子）。与非 OT 受试者相比，OT 在 12 周内改善了约 40% 受试者的嗅觉功能。初始评估和后续评估之间变化的比较表明，OT 组的总 KVSS II、阈值和识别分数的嗅觉结果明显优于非 OT 组。 OT后嗅觉改善程度受初始评分影响。本研究证明了 OT 对 PIOD 患者的影响。这项研究的一个有意义的贡献是，韩国患者使用他们熟悉的气味进行测试，并与对照组进行比较。
Postinfectious olfactory dysfunction (PIOD) is the most common etiology of olfactory dysfunction, and olfactory training (OT) is an accepted treatment modality for PIOD. Some studies have investigated OT in Korean patients, but they involved odorants unfamiliar to Koreans or had no control group. The aim of this study was to verify the efficacy of OT in PIOD patients, using odorants familiar to Koreans and including a control group. We enrolled a total of 104 Korean patients with PIOD over the 3-year study period. All participants were assessed using endoscopy and an olfactory function test at the baseline assessment and 3 months after OT. The olfactory function test was performed using the Korean version of Sniffin’ stick (KVSS) II. Nasal and psychological function was evaluated using a visual analog scale and the Mini-Mental State Examination. OT was performed over a period of 3 months, using five odorants (rose, lemon, cinnamon, orange, and peach). OT improved olfactory function in approximately 40% of subjects over a period of 12 weeks compared to non-OT subjects. A comparison of changes between the initial and follow-up assessments demonstrated that the OT group had significantly better olfactory results for the total KVSS II, threshold, and identification scores than the non-OT group. The degree of olfactory improvement after OT was affected by the initial score. The effects of OT in patients with PIOD were demonstrated in this study. A meaningful contribution of this study is that Korean patients were tested using odors familiar to them in comparison with a control group.
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