A multisite study of the clinical diagnosis of different autism spectrum disorders.
A multisite study of the clinical diagnosis of different autism spectrum disorders.
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DOI：
10.1001/archgenpsychiatry.2011.148
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发表时间：
2012-03
影响因子：
--
通讯作者：
Risi, Susan
中科院分区：
文献类型：
--
作者：
Lord, Catherine;Petkova, Eva;Hus, Vanessa;Gan, Weijin;Lu, Feihan;Martin, Donna M.;Ousley, Opal;Guy, Lisa;Bernier, Raphael;Gerdts, Jennifer;Algermissen, Molly;Whitaker, Agnes;Sutcliffe, James S.;Warren, Zachary;Klin, Ami;Saulnier, Celine;Hanson, Ellen;Hundley, Rachel;Piggot, Judith;Fombonne, Eric;Steiman, Mandy;Miles, Judith;Kanne, Stephen M.;Goin-Kochel, Robin P.;Peters, Sarika U.;Cook, Edwin H.;Guter, Stephen;Tjernagel, Jennifer;Green-Snyder, Lee Anne;Bishop, Somer;Esler, Amy;Gotham, Katherine;Luyster, Rhiannon;Miller, Fiona;Olson, Jennifer;Richler, Jennifer;Risi, Susan
特定自闭症谱系障碍（自闭症障碍，广泛性发育障碍-未另行说明，伯格障碍）的临床最佳估计诊断已被用作诊断金标准，即使来自标准化仪器的信息可用。为了确定不同自闭症谱系障碍的行为表型和临床诊断之间的关系是否在12所大学的网站上有所不同。多中心观察性研究，收集遗传研究的临床表型数据（诊断、发育和人口统计学）。分类树被用来确定预测诊断的特征，跨站点和站点内。参与者通过12所大学的自闭症服务提供者招募到自闭症的遗传研究中。2102名先证者（1814名男性），年龄在4至18岁之间（M年龄=8.93，SD=3.5岁），符合自闭症诊断访谈修订版和自闭症诊断观察时间表上的自闭症谱系标准，并有自闭症谱系障碍的临床诊断。通过诊断、认知和行为测量的标准化评分预测的最佳临床诊断估计。虽然标准化测量的分数分布在不同地点是相似的，但在特定自闭症谱系障碍的最佳估计临床诊断中出现了显着的地点差异。临床诊断和标准化评分之间的关系，特别是言语智商，语言水平和核心诊断特征，在信息权重和截止值方面各不相同。自闭症谱系障碍的分类诊断亚型之间的临床区别是不可靠的，即使在网站上有充分的文件保真度使用标准化的诊断工具。结果支持从现有的自闭症谱系障碍的亚组到社会影响和固定，重复行为的核心特征的维度描述，以及语言水平和认知功能等特征。
Clinical best estimate diagnoses of specific autism spectrum disorders (autistic disorder, pervasive developmental disorder-not otherwise specified, Asperger’s disorder) have been used as the diagnostic gold standard, even when information from standardized instruments is available. To determine if the relationships between behavioral phenotypes and clinical diagnoses of different autism spectrum disorders vary across 12 university-based sites. Multi-site observational study collecting clinical phenotype data (diagnostic, developmental and demographic) for genetic research. Classification trees were employed to identify characteristics that predicted diagnosis across and within sites. Participants were recruited through 12 university-based autism service providers into a genetic study of autism. 2102 probands (1814 males) between 4 and 18 years of age (M age=8.93, SD=3.5 years) who met autism spectrum criteria on the Autism Diagnostic Interview–Revised and Autism Diagnostic Observation Schedule and had a clinical diagnosis of an autism spectrum disorder. Best estimate clinical diagnoses predicted by standardized scores from diagnostic, cognitive, and behavioral measures. Though distributions of scores on standardized measures were similar across sites, significant site differences emerged in best estimate clinical diagnoses of specific autism spectrum disorders. Relationships between clinical diagnoses and standardized scores, particularly verbal IQ, language level and core diagnostic features, varied across sites in weighting of information and cut-offs. Clinical distinctions among categorical diagnostic subtypes of autism spectrum disorders were not reliable even across sites with well-documented fidelity using standardized diagnostic instruments. Results support the move from existing sub-groupings of autism spectrum disorders to dimensional descriptions of core features of social affect and fixated, repetitive behaviors, together with characteristics such as language level and cognitive function.
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影响因子：
3.9
作者：
Gotham, Katherine;Pickles, Andrew;Lord, Catherine
通讯作者：
Lord, Catherine
自闭症诊断观察表： 提高诊断有效性的修订算法
影响因子：
3.9
作者：
Gotham, Katherine;Risi, Susan;Lord, Catherine
通讯作者：
Lord, Catherine
影响因子：
3.6
作者：
Anderson, Deborah K.;Oti, Rosalind S.;Welch, Kathleen
通讯作者：
Welch, Kathleen
DOI：
10.1111/j.1469-7610.1995.tb01669.x
发表时间：
1995-11-01
影响因子：
7.6
作者：
Lord, C
通讯作者：
Lord, C
DOI：
10.1097/01.chi.0000227880.42780.0e
发表时间：
2006-09-01
影响因子：
13.3
作者：
Risi, Susan;Lord, Catherine;Pickles, Andrew
通讯作者：
Pickles, Andrew