Cohort profile: The Endometriosis pain QUality aftEr Surgical Treatment (EndoQUEST) Study.
Cohort profile: The Endometriosis pain QUality aftEr Surgical Treatment (EndoQUEST) Study.
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DOI：
10.1371/journal.pone.0269858
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
子宫内膜异位症影响育龄女性，在症状表现、形态学特征和治疗反应方面差异很大。大多数研究在成年人中进行，调查糖尿病相关手术后症状复发。建立了手术治疗后子宫内膜异位症疼痛质量（EndoQUEST）研究，以评估与青少年和年轻人子宫内膜异位症相关手术后疼痛补救和生活质量改善相关的特征和生物标志物。本文描述了EndoQUEST方法，总结了基线描述性因素，并比较了参与者保留状态的特征。我们招募了100名年龄在12-23岁之间的经手术证实的子宫内膜异位症参与者，他们在三个时间点提供了关于生殖和行为因素，疼痛特征和生活质量的问卷数据;术前，术后6周至26周，术后1年。在这100名参与者中，88人在所有三个时间点提供了血液和/或唾液样本，而12人仅在手术前和手术后6至26周提供了血液和/或唾液样本。几乎没有证据表明术后1年因疼痛症状而失访，因为术后1年完成问卷调查的参与者与未完成问卷调查的参与者之间的疼痛和生活质量特征相似。利用这些纵向数据的分析将促进患有子宫内膜异位症的青少年和年轻人的个性化治疗决策。
Endometriosis affects reproductive-aged females and varies considerably in terms of symptom presentation, morphologic features, and treatment response. Most studies investigating symptom recurrence after an endometriosis-related surgery have been conducted among adults. The Endometriosis pain QUality aftEr Surgical Treatment (EndoQUEST) Study was established to assess characteristics and biomarkers that are associated with pain remediation and improved quality of life after an endometriosis-related surgery among adolescents and young adults. This paper describes the EndoQUEST methodology, summarizes baseline descriptive factors, and compares characteristics by participant retention status. We enrolled 100 surgically-confirmed endometriosis participants aged 12–23 years who provided questionnaire data on reproductive and behavioral factors, pain characteristics and quality of life at three time points; before surgery, 6 weeks to 26 weeks after surgery, and 1 year after surgery. Among these 100 participants, 88 provided blood and/or saliva at all three time points, while 12 provided blood and/or saliva samples only before surgery and 6 to 26 weeks after surgery. There was little evidence of lost to follow-up at 1 year after surgery due to pain symptoms, as pain and quality of life characteristics were similar between participants who completed the questionnaire 1 year after surgery and those who did not. Analyses utilizing these longitudinal data will advance personalized treatment decision making for adolescents and young adults with endometriosis.
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影响因子：
6.7
作者：
Becker, Christian M.;Laufer, Marc R.;Stratton, Pamela;Hummelshoj, Lone;Missmer, Stacey A.;Zondervan, Krina T.;Adamson, G. David
通讯作者：
Adamson, G. David
影响因子：
9.8
作者：
DiVasta, Amy D.;Vitonis, Allison F.;Missmer, Stacey A.
通讯作者：
Missmer, Stacey A.
DOI：
10.4293/jsls.2015.00019
发表时间：
2015-04-01
影响因子：
1.5
作者：
Dun, Erica C.;Kho, Kimberly A.;Nezhat, Ceana H.
通讯作者：
Nezhat, Ceana H.
影响因子：
6.1
作者：
Abbott, JA;Hawe, J;Garry, R
通讯作者：
Garry, R
影响因子：
4.1
作者：
Audebert, Alain;Lecointre, Lise;Akladios, Cherif
通讯作者：
Akladios, Cherif