The mediating effect of prefrontal asymmetry on the relationship between the COMT Val(158)Met SNP and trait consummatory positive affect.
The mediating effect of prefrontal asymmetry on the relationship between the COMT Val(158)Met SNP and trait consummatory positive affect.
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DOI：
10.1080/02699931.2014.951030
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发表时间：
2015
影响因子：
2.6
通讯作者：
Shankman SA
中科院分区：
文献类型：
--
作者：
Katz AC;Sarapas C;Bishop JR;Patel SR;Shankman SA
COMT基因中的Val 158 Met rs 4680多态性调节前额叶皮层（PFC）中的多巴胺catalysts。多巴胺的参与奖励经验表明，那些与Met变异可能表现出特质水平的敏感性，奖励由于更多的突触后多巴胺在PFC。这种关联的生理介质可能是更大的相对左不对称的PFC，一个假定的生物标志物的特质积极情绪。120名参与者在一项任务中测量了脑电图，该任务评估了奖励处理的两个方面：奖励前预期和奖励后完成情感。参与者提供了遗传学样本，并完成了时间体验的快乐量表，评估特质水平的预期和完善的积极影响。Met携带者的TEPS-消费评分较高。这种效果是介导的更大的相对左激活后奖励阶段的任务。没有观察到奖励前阶段的影响。结果表明，额叶不对称是COMT基因型和特质奖励反应之间的内表型。
The Val158Met rs4680 polymorphism in the COMT gene regulates dopamine catabolism in the prefrontal cortex (PFC). Dopamine’s involvement in reward experience suggests those with the Met variant may exhibit trait-level sensitivity to reward due to more post-synaptic dopamine in the PFC. A physiological mediator of this association may be greater relative left asymmetry in the PFC, a putative biomarker for trait positive emotionality. Electroencephalograms of 120 participants were measured during a task that assesses two aspects of reward processing: pre-reward anticipation and post-reward consummatory affect. Participants provided genetics samples and completed the Temporal Experience of Pleasure Scale, which assesses trait-level anticipatory and consummatory positive affect. Met carriers had higher TEPS-Consummatory scores. This effect was mediated by greater relative left activation in the post-reward phase of the task. No effects were observed for the pre-reward phase. Results suggest that frontal asymmetry is an endophenotype between COMT genotype and trait reward responsivity.
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