Novel biomarkers of inflammation in heart failure with preserved ejection fraction: analysis from a large prospective cohort study.
Novel biomarkers of inflammation in heart failure with preserved ejection fraction: analysis from a large prospective cohort study.
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DOI：
10.1186/s12872-022-02656-z
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发表时间：
2022-05-14
影响因子：
2.1
通讯作者：
中科院分区：
文献类型：
--
作者：
射血分数保留的心力衰竭 (HFpEF) 是一种由多种原因引起的综合征，包括无法解决的炎症、内皮功能障碍和多器官缺陷。本研究的目的是确定 HFpEF 的新预测因子。
该研究分析了动脉粥样硬化多种族研究 (MESA)，以评估特定炎症标志物与新发 HFpEF 的关联（白细胞介素 2 [IL-2]、基质金属蛋白酶 3 [MMP3]、大分子低密度脂蛋白胆固醇 [LDL-C] 和中型高密度脂蛋白胆固醇 [HDL-C]）。该研究纳入了基线时没有心血管疾病的 45 至 84 岁男性和女性。主要结果是假设的炎症标记物与新发 HFpEF 与没有新发心力衰竭的参与者之间的多变量关联。缺少数据的参与者被排除在外。
目前的分析包括 6814 名参与者，其中 53% 是女性，平均年龄为 62 岁。在整个队列中，151 名 (2.2%) 参与者被诊断为 HFpEF，146 名 (2.1%) 参与者被诊断为射血分数降低心力衰竭 (HFrEF)。参与者的心力衰竭结果随访时间中位数为 13.9 年。 2861 名参与者可获得基线 IL-2。多变量分析包括 2792 名参与者。其中，2668 人未发生心力衰竭，62 人发生 HFpEF，47 人发生 HFrEF，15 人发生未分类心力衰竭。在多元回归模型中，IL-2 与新发 HFpEF 相关（OR，1.00058；95% 置信区间，1.00014 至 1.00102，p = 0.009），但与新发 HFrEF 无关。在多变量分析中，MMP3、大 LDL-C 和中 HDL-C 与 HFpEF 或 HFrEF 无关。
这些发现预示着 IL-2 是 HFpEF 发病机制中次优炎症的重要组成部分。
在线版本包含可在 10.1186/s12872-022-02656-z 获取的补充材料。
Heart failure with preserved ejection fraction (HFpEF) is a syndrome with a heterogeneous cluster of causes, including non-resolving inflammation, endothelial dysfunction, and multi-organ defects. The present study’s objective was to identify novel predictors of HFpEF. The study analyzed the Multi-Ethnic Study of Atherosclerosis (MESA) to assess the association of specific markers of inflammation with new onset of HFpEF (interleukin-2 [IL-2], matrix metalloproteinase 3 [MMP3], large low-density lipoprotein cholesterol [LDL-C], and medium high-density lipoprotein cholesterol [HDL-C]). The study included men and women 45 to 84 years of age without cardiovascular disease at baseline. The primary outcome was the multivariate association of the hypothesized markers of inflammation with new-onset of HFpEF versus participants without new-onset heart failure. Participants with missing data were excluded. The present analysis included 6814 participants, 53% female, with a mean age of 62 years. Among the entire cohort, HFpEF was diagnosed in 151 (2.2%) participants and heart failure with reduced ejection fraction (HFrEF) was diagnosed in 146 (2.1%) participants. Participants were followed for the outcome of heart failure for a median 13.9 years. Baseline IL-2 was available for 2861 participants. The multivariate analysis included 2792 participants. Of these, 2668 did not develop heart failure, 62 developed HFpEF, 47 developed HFrEF, and 15 developed unclassified heart failure. In the multivariate regression model, IL-2 was associated with new-onset HFpEF (OR, 1.00058; 95% confidence interval, 1.00014 to 1.00102, p = 0.009) but not new-onset HFrEF. In multivariate analysis, MMP3, large LDL-C, and medium HDL-C were not associated with HFpEF or HFrEF. These findings portend IL-2 as an important component of suboptimal inflammation in the pathogenesis of HFpEF. The online version contains supplementary material available at 10.1186/s12872-022-02656-z.
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影响因子：
4.6
作者：
Lakhani I;Wong MV;Hung JKF;Gong M;Waleed KB;Xia Y;Lee S;Roever L;Liu T;Tse G;Leung KSK;Li KHC
通讯作者：
Li KHC
影响因子：
3.8
作者：
Gaziano L;Cho K;Djousse L;Schubert P;Galloway A;Ho YL;Kurgansky K;Gagnon DR;Russo JP;Di Angelantonio E;Wood AM;Danesh J;Gaziano JM;Butterworth AS;Wilson PWF;Joseph J
通讯作者：
Joseph J
影响因子：
7.3
作者：
Halade GV;Norris PC;Kain V;Serhan CN;Ingle KA
通讯作者：
Ingle KA
影响因子：
3.8
作者：
Bakhshi, Hooman;Varadarajan, Vinithra;Lima, Joao A. C.
通讯作者：
Lima, Joao A. C.
DOI：
10.1161/circheartfailure.112.972828
发表时间：
2013-03
期刊：
Circulation. Heart failure
影响因子：
--
作者：
Ho JE;Lyass A;Lee DS;Vasan RS;Kannel WB;Larson MG;Levy D
通讯作者：
Levy D