Neural correlates of variations in event processing during learning in central nucleus of amygdala.
Neural correlates of variations in event processing during learning in central nucleus of amygdala.
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DOI：
10.1016/j.neuron.2010.11.019
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发表时间：
2010-12-09
期刊：
影响因子：
16.2
通讯作者：
Schoenbaum, Geoffrey
中科院分区：
文献类型：
--
作者：
Calu, Donna J.;Roesch, Matthew R.;Haney, Richard Z.;Holland, Peter C.;Schoenbaum, Geoffrey
事件处理中的注意力或变化有助于推动学习。病变研究表明，杏仁核中央核（CeA）参与了这一过程，特别是当预期的奖励被忽略时。然而，病变研究不能明确指出CeA中的信息加工如何支持这种学习。为了解决这些问题，我们记录了执行任务的大鼠的CeA神经元，其中奖励被意外地传递或省略。我们发现，CeA神经元的活动在遗漏时选择性地增加，并随着学习而再次下降。放电增加与cea失活的注意力敏感测量相关。值得注意的是，CeA神经元没有对提示或意外奖励做出反应。这些结果表明，由于CeA在传递实际遗漏信号方面的特定作用，而不是更普遍地参与传递期望、错误或奖励价值的信号，因此它有助于对奖励遗漏的学习。
Attention or variations in event processing help drive learning. Lesion studies have implicated the central nucleus of the amygdala (CeA) in this process, particularly when expected rewards are omitted. However, lesion studies cannot specify how information processing in CeA supports such learning. To address these questions, we recorded CeA neurons in rats performing a task in which rewards were delivered or omitted unexpectedly. We found that activity in CeA neurons increased selectively at the time of omission and declined again with learning. Increased firing correlated with CeA-inactivation sensitive measures of attention. Notably CeA neurons did not fire to the cues or in response to unexpected rewards. These results indicate that CeA contributes to learning in response to reward omission due to a specific role in signaling actual omission rather than a more general involvement in signaling expectancies, errors, or reward value.
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影响因子：
5.3
作者：
Holland, PC;Gallagher, M
通讯作者：
Gallagher, M
影响因子：
1.9
作者：
HOLLAND, PC;GALLAGHER, M
通讯作者：
GALLAGHER, M
影响因子：
3.4
作者：
McDannald, M;Kerfoot, E;Holland, PC
通讯作者：
Holland, PC
DOI：
10.1523/jneurosci.5781-09.2010
发表时间：
2010-02-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Roesch MR;Calu DJ;Esber GR;Schoenbaum G
通讯作者：
Schoenbaum G
DOI：
10.1037/0097-7403.31.2.155
发表时间：
2005-04-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES
影响因子：
--
作者：
Holland, PC;Kenmuir, C
通讯作者：
Kenmuir, C