Temporal variability of urinary phthalate metabolite levels in men of reproductive age.
Temporal variability of urinary phthalate metabolite levels in men of reproductive age.
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DOI：
10.1289/ehp.7212
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发表时间：
2004-12
影响因子：
10.4
通讯作者：
Calafat AM
中科院分区：
文献类型：
--
作者：
Hauser R;Meeker JD;Park S;Silva MJ;Calafat AM
邻苯二甲酸盐是一类广泛用于个人护理和其他消费品的多功能化学品。邻苯二甲酸盐的普遍使用导致人类通过多种来源和途径接触邻苯二甲酸盐，包括饮食摄入、皮肤吸收、吸入和含邻苯二甲酸盐的医疗器械的肠外接触。我们研究了11名男性在3个月内尿液邻苯二甲酸盐代谢物水平的时间变异性，这些男性在这段时间内每人收集了9份尿液样本。采用固相萃取-高效液相色谱-串联质谱法测定了8种邻苯二甲酸酯代谢物。进行统计分析以确定受试者之间和受试者内部的方差分配，以及单个尿液样本对受试者3个月平均暴露进行分类的敏感性和特异性。八种邻苯二甲酸酯中有五种经常被检测到。100%的样品中检出邻苯二甲酸一乙酯（MEP）；90%的样品中检出邻苯二甲酸一丁酯、邻苯二甲酸一苄酯、邻苯二甲酸二乙己酯（MEHP）和邻苯二甲酸一甲酯。虽然我们发现每个人的尿邻苯二甲酸盐代谢物水平每天和每月都有很大的变化，但单个尿液样本可以适度预测每个受试者在3个月内的暴露情况。灵敏度范围为0.56 ~ 0.74。在邻苯二甲酸盐代谢物中，受试者之间和受试者内部差异的程度以及单个尿液样本的预测能力都存在差异。特别是，单个尿液样本对MEP的预测效果最好，对MEHP的预测效果最差。这些结果表明，对于特定研究而言，最有效的暴露评估策略可能取决于所研究的邻苯二甲酸盐。
Phthalates are a family of multifunctional chemicals widely used in personal care and other consumer products. The ubiquitous use of phthalates results in human exposure through multiple sources and routes, including dietary ingestion, dermal absorption, inhalation, and parenteral exposure from medical devices containing phthalates. We explored the temporal variability over 3 months in urinary phthalate metabolite levels among 11 men who collected up to nine urine samples each during this time period. Eight phthalate metabolites were measured by solid-phase extraction–high-performance liquid chromatography–tandem mass spectrometry. Statistical analyses were performed to determine the between- and within-subject variance apportionment, and the sensitivity and specificity of a single urine sample to classify a subject’s 3-month average exposure. Five of the eight phthalates were frequently detected. Monoethyl phthalate (MEP) was detected in 100% of samples; monobutyl phthalate, monobenzyl phthalate, mono-2-ethylhexyl phthalate (MEHP), and monomethyl phthalate were detected in > 90% of samples. Although we found both substantial day-to-day and month-to-month variability in each individual’s urinary phthalate metabolite levels, a single urine sample was moderately predictive of each subject’s exposure over 3 months. The sensitivities ranged from 0.56 to 0.74. Both the degree of between- and within-subject variance and the predictive ability of a single urine sample differed among phthalate metabolites. In particular, a single urine sample was most predictive for MEP and least predictive for MEHP. These results suggest that the most efficient exposure assessment strategy for a particular study may depend on the phthalates of interest.
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影响因子：
5.4
作者：
Duty, SM;Silva, MJ;Hauser, R
通讯作者：
Hauser, R
影响因子：
2.5
作者：
NASSBERGER, L;ARBIN, A;OSTELIUS, J
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OSTELIUS, J
影响因子：
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作者：
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通讯作者：
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影响因子：
10.4
作者：
PECK, CC;ALBRO, PW
通讯作者：
ALBRO, PW