Impact of physical activity on inflammation: effects on cardiovascular disease risk and other inflammatory conditions.
Impact of physical activity on inflammation: effects on cardiovascular disease risk and other inflammatory conditions.
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DOI：
10.5114/aoms.2012.31614
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发表时间：
2012-11-09
期刊：
影响因子：
--
通讯作者：
Cicero A
中科院分区：
文献类型：
--
作者：
Ertek S;Cicero A
自19世纪以来，许多研究揭示了炎症在动脉粥样硬化中的作用，改变了我们对“由氧化脂蛋白引起的血管斑块”的看法，类似于“生锈的管道”，对许多细胞类型和细胞因子参与的疾病具有更复杂的机制。虽然“体力活动”和“体育锻炼”是两个在意义上有所不同的术语，但与久坐不动的生活方式相比，活跃的人患心血管疾病的风险更低，炎症标志物也更低。骨骼肌的活动揭示了在免疫系统和脂肪组织代谢中都有作用的“肌因子”。体外和离体研究表明，运动对炎症标志物有有益作用。同时，在临床研究中，一些相互矛盾的结果表明，活动类型、运动时间、身体成分、性别、种族和年龄可能会调节体育锻炼的抗炎作用。炎症性疾病患者的医学数据显示，运动对疾病活动评分、患者幸福感和炎症标志物都有有益影响。尽管最有益的活动类型和最相关的抗炎患者群体仍不清楚，但对老年人和成年人的研究总体上支持体育活动和适度运动的抗炎作用，可以建议有心血管风险的患者，如代谢综合征患者。
Since the 19th century, many studies have enlightened the role of inflammation in atherosclerosis, changing our perception of “vessel plaque due to oxidized lipoproteins”, similar to a “rusted pipe”, towards a disease with involvement of many cell types and cytokines with more complex mechanisms. Although “physical activity” and “physical exercise” are two terms with some differences in meaning, compared to sedentary lifestyle, active people have lower cardiovascular risk and lower inflammatory markers. Activities of skeletal muscle reveal “myokines” which have roles in both the immune system and adipose tissue metabolism. In vitro and ex-vivo studies have shown beneficial effects of exercise on inflammation markers. Meanwhile in clinical studies, some conflicting results suggested that type of activity, exercise duration, body composition, gender, race and age may modulate anti-inflammatory effects of physical exercise. Medical data on patients with inflammatory diseases have shown beneficial effects of exercise on disease activity scores, patient well-being and inflammatory markers. Although the most beneficial type of activity and the most relevant patient group for anti-inflammatory benefits are still not clear, studies in elderly and adult people generally support anti-inflammatory effects of physical activity and moderate exercise could be advised to patients with cardiovascular risk such as patients with metabolic syndrome.
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影响因子：
6.9
作者：
Balagopal, Prabhakaran (Babu);Gidding, Samuel S.;Funanage, Vicky L.
通讯作者：
Funanage, Vicky L.
影响因子：
5.3
作者：
Andersson, Jonas;Jansson, Jan-Hakan;Boman, Kurt
通讯作者：
Boman, Kurt
DOI：
10.1249/01.mss.0000227315.93351.8d
发表时间：
2006-07-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Degerstrom, Jorid;Osterud, Bjarne
通讯作者：
Osterud, Bjarne
DOI：
10.1152/ajpendo.00309.2007
发表时间：
2008-09-01
影响因子：
5.1
作者：
Bradley, Richard L.;Jeon, Justin Y.;Maratos-Flier, Eleftheria
通讯作者：
Maratos-Flier, Eleftheria
影响因子：
5.9
作者：
Bays, Harold E.
通讯作者：
Bays, Harold E.