Developmentally degraded directional selectivity of the auditory cortex can be restored by auditory discrimination training in adults
Developmentally degraded directional selectivity of the auditory cortex can be restored by auditory discrimination training in adults
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成人听觉皮层发育退化的方向选择性可以通过听觉辨别训练来恢复
DOI：
10.1016/j.bbr.2011.08.033
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发表时间：
2011-12
影响因子：
2.7
通讯作者：
Xinde Sun
中科院分区：
文献类型：
--
作者：
Yan Pan;Jiping Zhang;Rui Cai;Xiaoming Zhou;Xinde Sun
声音定位是听觉系统最重要的任务之一。研究表明，高强度训练可以修复由出生后早期脉冲噪声暴露引起的成人初级听觉皮层（A1）频率表征和时间信息处理的恶化。本研究表明，强化的声音位置识别训练改善了因出生后早期脉冲噪声暴露而退化的功能失调的声音方位选择性。在产后关键时期暴露于脉冲白噪声的大鼠成功地训练识别具有特定方位角的目标声音刺激，该目标声音刺激每天随机变化。与声音方位识别行为准确度的恢复一致，我们发现噪声培养大鼠A1神经元方位选择曲线的平均角度范围（AR）与对照大鼠没有显著差异，而未训练噪声培养大鼠A1神经元的平均AR显著高于对照大鼠，说明这些神经元的方向选择性较差。A1神经元的定向选择性通过训练被正常化，从而证明了感觉辨别训练作为一种策略的益处，可以恢复在皮层发育关键时期因感觉中断而受损的成年哺乳动物的听觉功能。
Sound localization is one of the most important tasks performed by the auditory system. Studies have shown that intensive training can remediate deteriorated frequency representations and temporal information processing in the adult primary auditory cortex (A1) induced by early post-natal pulsed noise exposure. Here we demonstrate that intensive sound location discrimination training improved the dysfunctional sound azimuth selectivity degraded by early post-natal pulsed noise exposure. Rats exposed to pulsed white noise during a post-natal critical period were successfully trained to identify a target sound stimulus with specific azimuth angle that changed daily on a random schedule. Consistent with recovery of behavioral accuracy for sound-azimuth discriminations, we found that the average angular range (AR) of A1 neuronal azimuth selective curves in trained noise-raised rats was not significantly different from that measured in control rats, while the average AR of A1 neurons in untrained noise-raised rats was significantly higher, indicating that these neurons were less direction selective. Directional selectivity of A1 neurons was normalized by training, thus demonstrating the benefits of sensory discrimination training as a strategy for restoring auditory function in adult mammals damaged by sensory disruption during critical periods of cortical development.
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影响因子：
2.8
作者：
Rutkowski, RG;Miasnikov, AA;Weinberger, NM
通讯作者：
Weinberger, NM
影响因子：
9.8
作者：
Kacelnik O;Nodal FR;Parsons CH;King AJ
通讯作者：
King AJ
DOI：
10.1073/pnas.1009433107
发表时间：
2010-08
期刊：
Proceedings of the National Academy of Sciences
影响因子：
--
作者：
Xiaoming Zhou;É. de Villers-Sidani;R. Panizzutti;M. Merzenich
通讯作者：
Xiaoming Zhou;É. de Villers-Sidani;R. Panizzutti;M. Merzenich
影响因子：
9.9
作者：
L. P. Sanchez-Longo;F. M. Forster
通讯作者：
L. P. Sanchez-Longo;F. M. Forster
影响因子：
3.9
作者：
CASPARY, DM;MILBRANDT, JC;HELFERT, RH
通讯作者：
HELFERT, RH