Delineating early developmental pathways to ADHD: Setting an international research agenda.
Delineating early developmental pathways to ADHD: Setting an international research agenda.
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描述了ADHD的早期发展途径：设定国际研究议程。
DOI：
10.1002/jcv2.12144
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发表时间：
2023-06
期刊：
影响因子：
--
通讯作者：
Jones, Emily J. H.
中科院分区：
文献类型：
--
作者：
Miller, Meghan;Arnett, Anne B.;Shephard, Elizabeth;Charman, Tony;Gustafsson, Hanna C.;Joseph, Heather M.;Karalunas, Sarah;Nigg, Joel T.;Polanczyk, Guilherme V.;Sullivan, Elinor L.;Jones, Emily J. H.
注意力缺陷/多动障碍（ADHD）是一种普遍的，损害性的，高度遗传的疾病，通常在童年中期诊断。然而，现在人们认识到，症状出现在发展的早期。研究重点是理解-使用多个分析单元-早期生命的级联（即，产前婴儿幼儿）的发育变化，以后将出现多动症有可能改变早期识别，预防和干预。为此，我们介绍了最近成立的早期ADHD联盟，一个国际网络的调查人员从事的前瞻性，纵向研究的风险ADHD开始在生命的早期，在一个发展的框架内进行，并纳入多方法的方法。该网络力求统一各种措施和方法，以增加数据共享的潜力和后续影响。这篇观点论文强调了研究ADHD的预诊断标志物以及ADHD风险和发展的潜在模型和机制的重要性，其长期目标是促进先发制人干预措施的发展，最大限度地减少ADHD症状对日常功能的影响，并最大限度地提高健康和发育结果。我们选择性地描述了与ADHD的理论模型和发展机制相关的这一领域的关键挑战和问题，并建议了科学的下一步，包括方法学，测量和研究设计考虑。然后，我们描述了先发制人的干预发展的潜在影响。最后，我们考虑其他问题，包括道德问题和纳入利益相关者的投入的关键价值。希望这一观点提出了一个研究议程，将加强合作努力，加快了解发育机制和早期ADHD表型的进展，并对婴儿，幼儿及其家庭的健康发育的早期干预增强产生影响。
Attention‐deficit/hyperactivity disorder (ADHD) is a prevalent, impairing, and highly heritable condition typically diagnosed in middle childhood. However, it is now recognized that symptoms emerge much earlier in development. Research focused on understanding—using multiple units of analysis—the cascade of early‐life (i.e., prenatal‐infant‐toddler) developmental changes that will later emerge as ADHD has the potential to transform early identification, prevention, and intervention. To this end, we introduce the recently established Early ADHD Consortium, an international network of investigators engaged in prospective, longitudinal studies of risk for ADHD beginning early in life, conducted within a developmental framework, and which incorporate multimethod approaches. This network seeks to harmonize measures and methodological approaches to increase the potential for data sharing and subsequent impact. This perspective paper highlights the importance of investigating pre‐diagnostic markers of ADHD, and potential models and mechanisms of ADHD risk and development, with the long‐term objective of facilitating development of preemptive interventions that will minimize the impact of ADHD symptoms on everyday functioning and maximize health and developmental outcomes. We selectively describe key challenges and questions for this field related to theoretical models and developmental mechanisms in ADHD and recommend next steps for the science, including methodological, measurement, and study design considerations. We then describe potential implications for preemptive intervention development. We conclude by considering other issues including ethical concerns and the critical value of incorporating stakeholder input. It is hoped that this perspective puts forth a research agenda that will enhance collaborative efforts and accelerate progress in understanding developmental mechanisms and the early ADHD phenotype, with implications for early intervention enhancement of healthy development for infants, young children, and their families.
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