Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study.
Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study.
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DOI：
10.1111/jcpp.13659
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发表时间：
2022-10
影响因子：
7.6
通讯作者：
Moffitt, Terrie E.
中科院分区：
文献类型：
--
作者：
Agnew-Blais, Jessica C.;Wertz, Jasmin;Arseneault, Louise;Belsky, Daniel W.;Danese, Andrea;Pingault, Jean-Baptiste;Polanczyk, Guilherme, V;Sugden, Karen;Williams, Benjamin;Moffitt, Terrie E.
混乱的家庭环境可能会导致儿童的注意力缺陷多动障碍(ADHD)症状。然而，ADHD的遗传风险也可能影响家庭混乱。这项研究调查了混乱家庭中的儿童是否有更多的ADHD症状，如果母亲和具有较高ADHD遗传风险的儿童生活在更混乱的家庭中，以及遗传风险和家庭混乱在整个童年期间ADHD症状的纵向过程中的联合关联。参与者是来自环境风险(E-Risk)纵向双胞胎研究的母亲和孩子，这是一项具有英国人口代表性的出生队列，由2232对双胞胎组成。在5岁、7岁、10岁和12岁 时评估儿童的多动症症状。研究人员在7岁、10岁和12岁时对家庭混乱进行了评级，并在12岁时根据母亲和双胞胎的自我报告对家庭混乱进行了评级。计算了母亲(n = 880)和双胞胎(n = 1,999)的全基因组多基因多基因风险分数(PR)；其中，n = 871名母亲和n = 1,925名儿童了解儿童多动症和家庭混乱的信息。生活在更混乱家庭的孩子有更高的ADHD症状。ADHD比率较高的母亲和儿童生活在更混乱的家庭中。儿童的多动症多动症与家庭混乱有关，而不是母亲的多动症，这表明了基因和环境之间的关联。在更混乱的家庭中，儿童的ADHD症状基线更高，症状下降的速度更慢。然而，敏感性分析估计，在家庭混乱与ADHD症状的关联中，基因与环境的相关性占了很大比例。儿童ADHD的遗传风险独立地与更高水平的家庭混乱有关，强调了儿童在塑造他们的家庭环境中的积极作用。我们的发现表明，家庭混乱在一定程度上反映了儿童患ADHD的遗传风险，这让人质疑家庭混乱是否直接影响儿童的核心ADHD症状。我们的发现强调了考虑父母和孩子的遗传风险与明显的环境暴露有关的重要性。
Chaotic home environments may contribute to children's attention‐deficit hyperactivity disorder (ADHD) symptoms. However, ADHD genetic risk may also influence household chaos. This study investigated whether children in chaotic households had more ADHD symptoms, if mothers and children with higher ADHD genetic risk lived in more chaotic households, and the joint association of genetic risk and household chaos on the longitudinal course of ADHD symptoms across childhood. Participants were mothers and children from the Environmental Risk (E‐Risk) Longitudinal Twin Study, a UK population‐representative birth cohort of 2,232 twins. Children's ADHD symptoms were assessed at ages 5, 7, 10 and 12 years. Household chaos was rated by research workers at ages 7, 10 and 12, and by mother's and twin's self‐report at age 12. Genome‐wide ADHD polygenic risk scores (PRS) were calculated for mothers (n = 880) and twins (n = 1,999); of these, n = 871 mothers and n = 1,925 children had information on children's ADHD and household chaos. Children in more chaotic households had higher ADHD symptoms. Mothers and children with higher ADHD PRS lived in more chaotic households. Children's ADHD PRS was associated with household chaos over and above mother's PRS, suggesting evocative gene–environment correlation. Children in more chaotic households had higher baseline ADHD symptoms and a slower rate of decline in symptoms. However, sensitivity analyses estimated that gene–environment correlation accounted for a large proportion of the association of household chaos on ADHD symptoms. Children's ADHD genetic risk was independently associated with higher levels of household chaos, emphasising the active role of children in shaping their home environment. Our findings suggest that household chaos partly reflects children's genetic risk for ADHD, calling into question whether household chaos directly influences children's core ADHD symptoms. Our findings highlight the importance of considering parent and child genetic risk in relation to apparent environmental exposures.
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DOI：
10.1093/bioinformatics/btu848
发表时间：
2015-05-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Euesden J;Lewis CM;O'Reilly PF
通讯作者：
O'Reilly PF
影响因子：
3.4
作者：
Kidd C;Palmeri H;Aslin RN
通讯作者：
Aslin RN
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
6.9
作者：
Owens, Julie Sarno;Goldfine, Matthew E.;Kaiser, Nina M.
通讯作者：
Kaiser, Nina M.
影响因子：
25.8
作者：
Leppert, Beate;Havdahl, Alexandra;Stergiakouli, Evie
通讯作者：
Stergiakouli, Evie