Occupational Exposure in the Lombardy Region (Italy) to SARS-CoV-2 Infection: Results from the MUSTANG-OCCUPATION-COVID-19 Study.
Occupational Exposure in the Lombardy Region (Italy) to SARS-CoV-2 Infection: Results from the MUSTANG-OCCUPATION-COVID-19 Study.
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DOI：
10.3390/ijerph18052567
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发表时间：
2021-03-04
影响因子：
--
通讯作者：
The Mustang-Occupation-Covid-Study Group
中科院分区：
文献类型：
--
作者：
Della Valle P;Fabbri M;Madotto F;Ferrara P;Cozzolino P;Calabretto E;D'Orso MI;Longhi E;Polosa R;Riva MA;Mazzaglia G;Sommese C;Mantovani LG;The Mustang-Occupation-Covid-Study Group
血清流行病学调查是估计SARS-CoV-2在一般人群或选定人群中传播的宝贵尝试。在此背景下，通过检测血清样本中的病毒特异性免疫球蛋白G和M (IgG/IgM)，开展了一项前瞻性观察性研究，以估计不同类别工人中SARS-CoV-2抗体的患病率和持久性以及与阳性相关的因素。参与者根据他们的工作活动被分为低暴露组和中高暴露组。3个月后再次联系抗体应答者进行随访。在2255名抽样工人中，4.8%检测出SARS-CoV-2 IgG/IgM抗体阳性，其中81.7%仅检测出IgG抗体。继续上班的工人、医护人员或至少经历过一种covid -19相关症状的工人更有可能检测出SARS-CoV-2抗体阳性。中高危组的SARS-CoV-2抗体患病率明显高于低危组（7.2% vs 3.0%, p < 0.0001）。随访3个月，81.3%的受试者仍有抗体应答。这项研究提供了意大利北部工人中SARS-CoV-2感染流行情况的重要信息，那里的COVID-19影响特别严重。提出的监测数据有助于完善目前对SARS-CoV-2预计造成的疾病负担的估计。
Sero-epidemiological surveys are valuable attempts to estimate the circulation of SARS-CoV-2 in general or selected populations. Within this context, a prospective observational study was conducted to estimate the prevalence and persistence of SARS-CoV-2 antibodies in different categories of workers and factors associated with positivity, through the detection of virus-specific immunoglobulin G and M (IgG/IgM) in serum samples. Enrollees were divided in low exposure and medium-high groups on the basis of their work activity. Antibody responders were re-contacted after 3 months for the follow-up. Of 2255 sampled workers, 4.8% tested positive for SARS-CoV-2 IgG/IgM antibodies, with 81.7% to IgG only. Workers who continued to go to their place of work, were healthcare workers, or experienced at least one COVID-19-related symptom were more likely to test positive for SARS-CoV-2 antibodies. SARS-CoV-2 antibodies prevalence was significantly higher in the medium-high risk vs. low-risk group (7.2% vs. 3.0%, p < 0.0001). At 3-month follow-up, 81.3% of subjects still had antibody response. This study provided important information of SARS-CoV-2 infection prevalence among workers in northern Italy, where the impact of COVID-19 was particularly intense. The presented surveillance data give a contribution to refine current estimates of the disease burden expected from the SARS-CoV-2.
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影响因子：
4.9
作者：
Marinaccio A;Boccuni F;Rondinone BM;Brusco A;D'Amario S;Iavicoli S
通讯作者：
Iavicoli S
影响因子：
24.8
作者：
Isho B;Abe KT;Zuo M;Jamal AJ;Rathod B;Wang JH;Li Z;Chao G;Rojas OL;Bang YM;Pu A;Christie-Holmes N;Gervais C;Ceccarelli D;Samavarchi-Tehrani P;Guvenc F;Budylowski P;Li A;Paterson A;Yue FY;Marin LM;Caldwell L;Wrana JL;Colwill K;Sicheri F;Mubareka S;Gray-Owen SD;Drews SJ;Siqueira WL;Barrios-Rodiles M;Ostrowski M;Rini JM;Durocher Y;McGeer AJ;Gommerman JL;Gingras AC
通讯作者：
Gingras AC
影响因子：
16.6
作者：
Bertuzzo, Enrico;Mari, Lorenzo;Rinaldo, Andrea
通讯作者：
Rinaldo, Andrea
影响因子：
168.9
作者：
Pollan, Marina;Perez-Gomez, Beatriz;Yotti, Raquel
通讯作者：
Yotti, Raquel
影响因子：
158.5
作者：
Gudbjartsson, Daniel F.;Norddahl, Gudmundur L.;Stefansson, Kari
通讯作者：
Stefansson, Kari