The association of whole grain consumption with incident type 2 diabetes: the Women's Health Initiative Observational Study.
The association of whole grain consumption with incident type 2 diabetes: the Women's Health Initiative Observational Study.
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DOI：
10.1016/j.annepidem.2013.03.010
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发表时间：
2013-06
影响因子：
5.6
通讯作者：
Margolis, Karen L.
中科院分区：
文献类型：
--
作者：
Parker, Emily D.;Liu, Simin;Van Horn, Linda;Tinker, Leslie F.;Shikany, James M.;Eaton, Charles B.;Margolis, Karen L.
全谷物可以通过减少能量摄入，防止体重增加和直接影响胰岛素抵抗来保护糖尿病。本研究通过一组绝经后妇女自我报告的药物使用情况，研究了全谷物和精制谷物与2型糖尿病（T2 D）发病率的关系。纳入了72，215名来自妇女健康倡议观察性研究的基线无糖尿病妇女。全谷物摄入量分为0、<0.5、0.5-1.0、1.0-<1.5、1.5-<2.0和≥2.0份/天。进行比例风险回归以估计风险比（HR）和95%置信区间，调整潜在混杂因素。在中位7.9年随访期间，有3，465例T2 D事件。根据年龄和能量摄入量/天进行调整后，连续增加全谷物消费类别与T2 D事件风险的统计学显著降低相关（HR = 1.00，0.83，0.73，0.69，0.61，0.57，趋势p <0.0001）。在调整混杂因素和其他饮食成分后，结果减弱。不吸烟者和体重保持在5磅以内的人，与吸烟者和体重增加较多的女性相比，全谷物摄入量较高，T2 D的风险降低得更大。这项大型前瞻性研究发现，绝经后妇女的全谷物摄入量与T2 D事件之间存在反向的剂量反应关系。
Whole grains may offer protection from diabetes by decreasing energy intake, preventing weight gain, and direct effects on insulin resistance. This study examined associations of whole and refined grains with incident type 2 diabetes (T2D) ascertained by self-reported medication use in a cohort of post-menopausal women. 72,215 women free of diabetes at baseline from the Women's Health Initiative Observational Study were included. Whole grain consumption was categorized as 0, <0.5, 0.5-1.0, 1.0-<1.5, 1.5-<2.0, and ≥2.0 servings/day. Proportional hazards regression was performed to estimate hazard ratios (HR) and 95% confidence intervals adjusting for potential confounders. There were 3,465 cases of incident T2D over median 7.9 years follow-up. Adjusted for age and energy intake/day, successively increasing categories of whole grain consumption were associated with statistically significant reduced risk of incident T2D (HRs= 1.00, 0.83, 0.73, 0.69, 0.61, 0.57, p for trend <0.0001). Results were attenuated after adjustment for confounders and other dietary components. Non-smokers and those who maintained their weight within 5 pounds had a greater reduced risk of T2D with higher consumption of whole grains than smokers and women who gained more weight. This large, prospective study found an inverse, dose-response relationship between whole grain consumption and incident T2D in postmenopausal women.
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影响因子：
7.1
作者：
Barclay, Alan W.;Petocz, Peter;Brand-Miller, Jennie C.
通讯作者：
Brand-Miller, Jennie C.
影响因子：
11.1
作者：
ATTVALL, S;FOWELIN, J;SMITH, U
通讯作者：
SMITH, U
影响因子：
7.1
作者：
McKeown, NM;Meigs, JB;Jacques, PF
通讯作者：
Jacques, PF
影响因子：
7.1
作者：
Jacobs, David R., Jr.;Andersen, Lene Frost;Blomhoff, Rune
通讯作者：
Blomhoff, Rune
DOI：
10.1080/07315724.2002.10719227
发表时间：
2002-08-01
影响因子：
3.5
作者：
Liu, SM
通讯作者：
Liu, SM