Selenol-Based Nucleophilic Reaction for the Preparation of Reactive Oxygen Species-Responsive Amphiphilic Diblock Copolymers
Selenol-Based Nucleophilic Reaction for the Preparation of Reactive Oxygen Species-Responsive Amphiphilic Diblock Copolymers
复制标题
基于硒醇的亲核反应制备活性氧响应性两亲二嵌段共聚物
作者：
安晓伟;陆伟红;朱健;潘向强;朱秀林
Selenide-containing amphiphilic copolymers have shown significant potential for application in drug release systems. Herein, we present a methodology for the design of a reactive oxygen species-responsive amphiphilic diblock selenide-labeled copolymer. This copolymer with controlled molecular weight and narrow molecular weight distribution was prepared by sequential organoselenium-mediated reversible addition fragmentation chain transfer (Se-RAFT) polymerization and selenol-based nucleophilic reaction. Nuclear magnetic resonance (NMR) and matrix-assisted laser desorption/ionization time-to-flight (MALDI-TOF) techniques were used to characterize its structure. Its corresponding nanomicelles successfully formed through self-assembly from the copolymer itself. Such nanomicelles could rapidly disassemble under oxidative conditions due to the fragmentation of the Se–C bond. Therefore, this type of nanomicelle based on selenide-labeled amphiphilic copolymers potentially provides a new platform for drug delivery.
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影响因子：
4.6
作者：
Jindong Zeng;Jian Zhu;Xiangqiang Pan;Zhengbiao Zhang;Nianchen Zhou;Zhenping Cheng;Wei Zhang-;Xiu-lin Zhu-Xiu
通讯作者：
Jindong Zeng;Jian Zhu;Xiangqiang Pan;Zhengbiao Zhang;Nianchen Zhou;Zhenping Cheng;Wei Zhang-;Xiu-lin Zhu-Xiu
DOI：
--
发表时间：
2010-12
期刊：
--
影响因子：
--
作者：
T. Wirth
通讯作者：
T. Wirth
影响因子：
4.6
作者：
Ma, Ning;Li, Ying;Zhang, Xi
通讯作者：
Zhang, Xi
影响因子：
6
作者：
T. Kwon;Koji Takagi;H. Kunisada;Y. Yuki
通讯作者：
T. Kwon;Koji Takagi;H. Kunisada;Y. Yuki
影响因子：
0.7
作者：
S. Salma;C. M. Le;Dong woo Kim;X. Cao;Y. Jeong;K. Lim
通讯作者：
S. Salma;C. M. Le;Dong woo Kim;X. Cao;Y. Jeong;K. Lim