Osteocyte primary cilium and its role in bone mechanotransduction.
Osteocyte primary cilium and its role in bone mechanotransduction.
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DOI：
10.1111/j.1749-6632.2009.05243.x
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发表时间：
2010-03
影响因子：
5.2
通讯作者：
Jacobs CR
中科院分区：
文献类型：
--
作者：
Temiyasathit S;Jacobs CR
骨是一种动态的组织，能够适应局部的载荷环境。机械力传导是细胞将机械力转化为生物化学信号的过程，对于维持骨骼健康和体内平衡非常重要。然而，尚不清楚是什么细胞机械传感器感知并启动这些信号级联。初级纤毛是从细胞体延伸到细胞外空间的孤立的刚性结构;因此，它们是骨中机械传感的主要候选者。它们已被证明在发育中至关重要，并且它们与其他组织类型（包括肝脏和肾脏）中的机械传感有关。本文综述了初级纤毛在骨力学信号转导中的作用及其可能的研究方向。
Bone is a dynamic tissue that adapts to its local loading environment. Mechanotransduction, the process by which cells convert mechanical forces into biochemical signals, is important for maintaining bone health and homeostasis. It is less clear, however, what the cellular mechanosensor(s) are that sense and initiate these signaling cascades. Primary cilia are solitary, rigid structures that extend from cell body into the extracellular space; as a result, they are prime candidates for mechanosensing in bone. They have been shown to be critical in development, and they have been implicated in mechanosensing in other tissue types including liver and kidney. This review discusses the potential for primary cilia to play an important role in bone mechanotransduction and possible avenues for future study.
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影响因子：
--
作者：
Jiang, JX;Cherian, PP
通讯作者：
Cherian, PP
影响因子：
2.4
作者：
Qin, YX;Kaplan, T;Rubin, C
通讯作者：
Rubin, C
DOI：
10.1006/bbrc.1995.2822
发表时间：
1995-12-14
影响因子：
3.1
作者：
KleinNulend, J;Semeins, CM;Burger, EH
通讯作者：
Burger, EH
DOI：
10.1007/bf02547216
发表时间：
1974-01-01
期刊：
CALCIFIED TISSUE RESEARCH
影响因子：
--
作者：
FEDERMAN, M;NICHOLS, G
通讯作者：
NICHOLS, G
影响因子：
3.2
作者：
McGlashan, Susan R.;Jensen, Cynthia G.;Poole, C. Anthony
通讯作者：
Poole, C. Anthony