Stainless Steel Hollow Microspheres for Arterial Embolization Hyperthermia
Stainless Steel Hollow Microspheres for Arterial Embolization Hyperthermia
复制标题
用于动脉栓塞热疗的不锈钢空心微球
DOI：
10.1007/s40846-017-0252-2
复制
发表时间：
2017-06
影响因子：
2
通讯作者：
Tang JT
中科院分区：
文献类型：
--
作者：
Wu Jianan;Wang Heng;Zhang Han;Wei Lanbin;Wang Xiaowen;Tang Jintian;Wang Xufei;Tang JT
目的寻找一种适用于动脉栓塞热疗（AEH）的新型微尺度介质。采用水射流分散法制备了空心和实心不锈钢微球。理论分析了它们在交变磁场中的功率吸收，发现尺寸越大、磁导率越小，发热量越大。较高的电场强度和频率也提高了加热功率。在相同条件下，空心微球的单位质量加热功率大于实心微球。对H1和S1进行了沿着显微观察、粒度分布、磁化曲线和加热功率测定。对最终筛选出的介体H1进行了体内致热试验、体外热疗试验和体外生物相容性试验。在低场强下，H1和S1的加热功率与理论值相符，但在强场强下，加热功率远低于理论值。H1的功率密度明显大于S1的功率密度，正如理论预测的那样。在磁场中注入H_1的兔耳温度保持在50 ℃ 10分钟。体外热疗试验显示其对癌细胞有显著的治疗效果。H1的细胞毒性分类为I级，认为无细胞毒性。不锈钢空心微球H1具有高效的热疗和杀伤肿瘤细胞的作用，且具有良好的生物相容性，是一种很有前途的AEH介导剂。
To find a novel microscaled mediator suitable for arterial embolization hyperthermia (AEH). Stainless steel microspheres including both hollow (H1) and solid ones (S1) were produced with dispersing molten steel stream by water jet. Theoretically analyzing the power absorption of them in alternating magnetic field revealed that larger size and smaller permeability led to more heat generation. Higher field intensity and frequency also improved the heating power. Given the same condition, heating power per unit mass was greater in hollow microsphere than solid one. Microscopic observations of H1 and S1 were conducted along with particle size distribution, magnetization curve and heating power measurement. In vivo heating test, in vitro hyperthermia test and in vitro biocompatibility test were conducted for the finally selected mediator H1. The measured heating power of H1 and S1 met the theoretical values in low intensity field, but was considerably below expectation in strong field. Power density of H1 was clearly greater than that of S1 as theoretically predicted. The temperature of a rabbit ear in magnetic field injected with H1 maintained 50 C for 10 min. In vitro hyperthermia test showed its outstanding treatment effectiveness for cancer cells. Cytotoxicity of H1 was categorized as Grade I, which is regarded as no cytotoxicity. Stainless steel hollow microsphere H1 was a promising mediator for AEH for its high efficiency in heating tumor region and killing cancer cells as well as good biocompatibility.
登录
查看更多内容
影响因子：
4.3
作者：
S. Haider;T. Cetas;James R. Wait;J. S. Chen
通讯作者：
S. Haider;T. Cetas;James R. Wait;J. S. Chen
DOI：
10.1109/9780470545188.ch1
发表时间：
1964
期刊：
--
影响因子：
--
作者：
近角 聡信;S. Charap
通讯作者：
近角 聡信;S. Charap
影响因子：
4.5
作者：
Lockman, PR;Koziara, JM;Allen, DD
通讯作者：
Allen, DD
影响因子：
2.5
作者：
Moroz, P;Jones, SK;Gray, BN
通讯作者：
Gray, BN
DOI：
10.1016/j.msec.2014.12.046
发表时间：
2015-03
期刊：
Materials science & engineering. C, Materials for biological applications
影响因子：
--
作者：
I. Smolkova;N. Kazantseva;Kira N. Makoveckaya;P. Smolka;P. Sáha;A. M. Granov
通讯作者：
I. Smolkova;N. Kazantseva;Kira N. Makoveckaya;P. Smolka;P. Sáha;A. M. Granov