Characterizing the spectrum of irritability in preadolescence: Dimensional and pragmatic applications.
Characterizing the spectrum of irritability in preadolescence: Dimensional and pragmatic applications.
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DOI：
10.1002/mpr.1988
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发表时间：
2023-11
影响因子：
3.1
通讯作者：
Wiggins, Jillian Lee
中科院分区：
文献类型：
--
作者：
Alam, Tasmia;Kirk, Nathan;Hirsch, Emily;Briggs-Gowan, Margaret;Wakschlag, Lauren S.;Roy, Amy Krain;Wiggins, Jillian Lee
使用青少年版本的多维评估档案脾气损失量表（MAPS - TL - youth），包括常见和发展特定项目，表征青春期前易怒（PA）的维度谱，这是一个强大的跨诊断脆弱性标志物。在此基础上，推导并验证临床优化的易怒筛选，以标记青春期前的精神病理风险。正常：异常易怒谱采用来自学龄前儿童多维评估研究（MAPS）研究PA波（n = 340）的MAPS - TL - Youth数据，通过项目反应理论建立模型。MAPS量表中的交叉核心项目和发展特定项目都被用来生成这个维度。然后使用逐步逻辑回归优化MAPS - TL -青少年易怒项目与儿童情感障碍和精神分裂症损害量表的关系，以生成临床优化的易怒筛选表。接收操作员特征分析确定了筛选者的易怒阈值。青年人在MAPS - TL - youth - self - report （MAPS - TL - youth - SR）上的易怒自我报告也首次被建模。易怒是单向度的，从轻微和常见到严重和罕见的行为。发展特定的项目允许检测更严重的易怒。筛选的项目被确定为与并发损伤有关。这些包括低挫折容忍度和病态的严重行为。临床优化的筛选器在并发易怒相关DSM障碍方面表现出非常好的敏感性（87%）和特异性（81%）。MAPS - TL - Youth - SR模型也得到了类似的结果。表征正常：青春期前易怒的异常谱促进了研究领域标准方法在这一发育时期的应用。这项基础工作产生了两种发育指定的青春期前易怒表征工具：一种细微的维度量表，用于精确表征整个正常-异常易怒谱，以及一种实用的、临床优化的筛选器，适用于现实世界。未来在机理和临床研究中的应用将对建立有效性和增量效用具有重要意义。
Characterize the dimensional spectrum of preadolescent (PA) irritability, a robust transdiagnostic vulnerability marker, using the youth version of the Multidimensional Assessment Profiles Temper Loss (MAPS‐TL‐Youth) scale including common and with developmentally specific items. Based on this, derive and validate a clinically optimized irritability screener to flag psychopathology risk in preadolescents. The normal:abnormal irritability spectrum was modeled using MAPS‐TL‐Youth data from the Multidimensional Assessment of Preschoolers Study (MAPS) Study PA wave (n = 340) via item response theory. Both cross‐cutting core items from the MAPS scales and developmentally specific items were used to generate this dimension. Stepwise logistic regression was then used to optimize MAPS‐TL‐Youth irritability items in relation to Kiddie Schedule of Affective Disorders and Schizophrenia impairment to generate a clinically optimized irritability screener. Receiver operator characteristic analysis identified the irritability threshold for the screener. For the first time, youth self‐report of their own irritability on the MAPS‐TL was also modeled via the MAPS‐TL‐Youth‐Self‐Report (MAPS‐TL‐Youth‐SR). Irritability was unidimensional and ranged from mild and common to severe and rare behaviors. Developmentally specific items allowed detection of more severe irritability. Items for the screener were identified in relation to concurrent impairment. These included low frustration tolerance and pathognomonic severe behaviors. The clinically optimized screener demonstrated very good sensitively (87%) and specificity (81%) in regard to concurrent irritability‐related DSM disorders. Modeling of the MAPS‐TL‐Youth‐SR yielded similar results. Characterizing the normal: abnormal spectrum of irritability in preadolescence advances application of Research Domain Criteria methods to this developmental period. This foundational work yielded two developmentally specified tools for irritability characterization in preadolescence: a nuanced dimensional scale to precisely characterize the full normal‐abnormal irritability spectrum, and a pragmatic, clinically optimized screener suitable for real world use. Future application in mechanistic and clinical studies will be important for establishing validity and incremental utility.
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影响因子：
3.1
作者：
Hirsch, Emily;Alam, Tasmia;Kirk, Nathan;Bevans, Katherine B.;Briggs-Gowan, Margaret;Wakschlag, Lauren S.;Wiggins, Jillian L.;Roy, Amy K.
通讯作者：
Roy, Amy K.
DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
DOI：
10.1146/annurev-clinpsy-032816-044941
发表时间：
2017-01-01
期刊：
ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 13
影响因子：
--
作者：
Brotman, Melissa A.;Kircanski, Katharina;Leibenluft, Ellen
通讯作者：
Leibenluft, Ellen
DOI：
10.1016/j.jaac.2018.02.010
发表时间：
2018-05-01
影响因子：
13.3
作者：
Pagliaccio, David;Pine, Daniel S.;Leibenluft, Ellen
通讯作者：
Leibenluft, Ellen
DOI：
10.1016/j.jaac.2016.04.014
发表时间：
2016-07
影响因子：
13.3
作者：
Vidal-Ribas P;Brotman MA;Valdivieso I;Leibenluft E;Stringaris A
通讯作者：
Stringaris A