Renally Excretable Silver Telluride Nanoparticles as Contrast Agents for X-ray Imaging.
Renally Excretable Silver Telluride Nanoparticles as Contrast Agents for X-ray Imaging.
复制标题
肾可排出的碲化银纳米粒子作为X射线成像的造影剂。
DOI：
10.1021/acsami.2c06190
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发表时间：
2022-08-03
影响因子：
9.5
通讯作者：
Cormode, David P.
中科院分区：
文献类型：
--
作者：
Nieves, Lenitza M.;Dong, Yuxi C.;Rosario-Berrios, Derick N.;Mossburg, Katherine;Hsu, Jessica C.;Cramer, Gwendolyn M.;Busch, Theresa M.;Maidment, Andrew D. A.;Cormode, David P.
纳米粒子在生物医学成像、药物传递和治疗方面的应用引起了人们的广泛关注。碲化银纳米颗粒（Ag2Te NPs）最近被证明是非常有效的计算机断层扫描（CT）和双能乳房x线造影造影剂，具有良好的稳定性和生物相容性，以及许多其他生物医学用途的潜力。尽管Ag2Te NPs在疾病诊断和治疗方面具有许多优点，但其临床翻译依赖于实现高水平的排泄，这是许多纳米颗粒类型的限制。在这项工作中，我们合成并表征了Ag2Te NPs库，并确定了导致核心尺寸为3 nm且可肾脏排泄的条件。我们发现这些纳米颗粒具有良好的生物相容性，强x射线造影剂产生，和快速的肾脏清除。我们的CT数据显示，纳米颗粒在给药2小时内发生肾脏消除。此外，生物分布数据表明，93%的注射剂量（%ID）在24小时内从主要器官排出，95% ID在7天内排出，97% ID在28天内排出，组织学分析所研究的组织无急性毒性迹象。据我们所知，这种肾脏清除率是Ag2Te NP报道的最好的，同时与任何类型的纳米颗粒报道的最高肾脏清除率相当。总之，本文提出的结果表明，GSH-Ag2Te NPs作为x射线造影剂在未来具有临床转化的潜力。
The use of nanoparticles in the biomedical field has gained much attention due to their applications in biomedical imaging, drug delivery, and therapeutics. Silver telluride nanoparticles (Ag2Te NPs) have been recently shown to be highly effective computed tomography (CT) and dual-energy mammography contrast agents with good stability and biocompatibility, as well as to have potential for many other biomedical purposes. Despite their numerous advantageous properties for diagnosis and treatment of disease, the clinical translation of Ag2Te NPs is dependent on achieving high levels of excretion, a limitation for many nanoparticle types. In this work, we have synthesized and characterized a library of Ag2Te NPs and identified conditions that led to 3 nm core size and were renally excretable. We found that these nanoparticles have good biocompatibility, strong X-ray contrast generation, and rapid renal clearance. Our CT data suggest that renal elimination of nanoparticles occurred within 2 h of administration. Moreover, biodistribution data indicate that 93% of the injected dose (%ID) has been excreted from the main organs in 24 h, 95% ID in 7 days, and 97% ID in 28 days with no signs of acute toxicity in the tissues studied under histological analysis. To our knowledge, this renal clearance is the best reported for Ag2Te NP, while being comparable to the highest renal clearance reported for any type of nanoparticle. Together, the results herein presented suggest the use of GSH-Ag2Te NPs as an X-ray contrast agent with the potential to be clinically translated in the future.
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影响因子：
6.7
作者：
Hsu JC ;Naha PC ;Lau KC ;Chhour P ;Hastings R ;Moon BF ;Stein JM ;Witschey WRT ;McDonald ES ;Maidment ADA ;Cormode DP
通讯作者：
Cormode DP
影响因子：
5.4
作者：
Metselaar, Josbert M.;Lammers, Twan
通讯作者：
Lammers, Twan
影响因子：
3.9
作者：
Moaseri, Ehsan;Bollinger, Jonathan A.;Truskett, Thomas M.
通讯作者：
Truskett, Thomas M.
影响因子：
19.7
作者：
FitzGerald, Paul F.;Colborn, Robert E.;Yeh, Benjamin M.
通讯作者：
Yeh, Benjamin M.
DOI：
10.1002/wnan.1642
发表时间：
2020-11
期刊：
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
影响因子：
--
作者：
Hsu JC;Nieves LM;Betzer O;Sadan T;Noël PB;Popovtzer R;Cormode DP
通讯作者：
Cormode DP