An all-in-one nanoparticle (AION) contrast agent for breast cancer screening with DEM-CT-MRI-NIRF imaging.
An all-in-one nanoparticle (AION) contrast agent for breast cancer screening with DEM-CT-MRI-NIRF imaging.
复制标题
DOI：
10.1039/c8nr03741h
复制
发表时间：
2018-09-20
期刊：
影响因子：
6.7
通讯作者：
Cormode DP
中科院分区：
文献类型：
--
作者：
Hsu JC ;Naha PC ;Lau KC ;Chhour P ;Hastings R ;Moon BF ;Stein JM ;Witschey WRT ;McDonald ES ;Maidment ADA ;Cormode DP
传统的X射线乳腺摄影对致密乳腺的诊断敏感性较低。因此，替代的对比度增强筛查工具，如双能乳腺X线摄影（DEM），计算机断层扫描（CT），磁共振成像（MRI）和近红外荧光（NIRF）成像正在使用或研究这些妇女。然而，目前可用的造影剂是不理想的，具有安全性问题，并且每种成像技术需要不同的造影剂。因此，我们试图开发一种对每种乳腺成像方式都有效的多模式造影剂，以简化诊断过程并解决现有造影剂的问题。在此，我们提出了一种新的“一体化”纳米颗粒（AION）多模态成像探针，具有有效的DEM，CT，MRI和NIRF对比特性和改善的生物相容性。通过将近红外荧光团（DiR）、银硫化物纳米颗粒（Ag 2S-NP）和氧化铁纳米颗粒（IO-NP）共封装在聚乙二醇化胶束中形成AION。AION显示出可忽略的细胞毒性，这与其最小的银离子释放曲线一致。如体模成像中所示，AION与所有成像模式产生强对比度。AION允许体内肿瘤成像，如通过注射后对比度的增加所证明的。这项研究表明，AION作为一种有效的多模态造影剂的潜力，乳腺癌诊断与一系列的成像方法。
Conventional X-ray mammography has low diagnostic sensitivity for women with dense breasts. As a result, alternative contrast-enhanced screening tools such as dual energy mammography (DEM), computed tomography (CT), magnetic resonance imaging (MRI), and near-infrared fluorescence (NIRF) imaging are being used or investigated for these women. However, currently available contrast agents are non-ideal, have safety issues, and each imaging technique requires a different contrast agent. We therefore sought to develop a multimodal contrast agent that is functional for each breast imaging modality to simplify the diagnosis process and address the issues of existing contrast agents. Herein, we present a novel “all-in-one” nanoparticle (AION) multimodal imaging probe that has potent DEM, CT, MRI, and NIRF contrast properties and improved biocompatibility. AION were formed by co-encapsulation of a near-infrared fluorophore (DiR), silver sulfide nanoparticles (Ag2S-NP), and iron oxide nanoparticles (IO-NP) in PEGylated micelles. AION showed negligible cytotoxicity, which was in agreement with its minimal silver ion release profiles. AION generated strong contrast with all imaging modalities as demonstrated in phantom imaging. AION allowed in vivo tumor imaging as evidenced by the increase in contrast after injection. This study indicates the potential of AION as an effective multimodal contrast agent for breast cancer diagnosis with a range of imaging methods.
登录
查看更多内容
影响因子：
11.4
作者：
Levard, Clement;Hotze, Ernest M.;Colman, Benjamin P.;Dale, Amy L.;Truong, Lisa;Yang, X. Y.;Bone, Audrey J.;Brown, Gordon E., Jr.;Tanguay, Robert L.;Di Giulio, Richard T.;Bernhardt, Emily S.;Meyer, Joel N.;Wiesner, Mark R.;Lowry, Gregory V.
通讯作者：
Lowry, Gregory V.
二氧化硅封装的银纳米颗粒的开发是用于双能乳房X线摄影的对比剂。
影响因子：
5.9
作者：
Karunamuni R;Naha PC;Lau KC;Al-Zaki A;Popov AV;Delikatny EJ;Tsourkas A;Cormode DP;Maidment AD
通讯作者：
Maidment AD
影响因子：
39.2
作者：
Carney, PA;Miglioretti, DL;Ballard-Barbash, R
通讯作者：
Ballard-Barbash, R
影响因子：
19.7
作者：
Jochelson, Maxine S.;Dershaw, D. David;Morris, Elizabeth A.
通讯作者：
Morris, Elizabeth A.
影响因子：
3.9
作者：
Farrell, Zachary;Shelton, Cameron;Green, David
通讯作者：
Green, David