Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer.
Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer.
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DOI：
10.1038/sj.bjc.6605532
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发表时间：
2010-02-16
影响因子：
8.8
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中科院分区：
文献类型：
--
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巨噬细胞抑制性细胞因子-1（MIC-1）是全身炎症和营养消耗的潜在调节剂，这两者都是食管-胃癌（OGC）的不良预后因素。在新诊断的OGC患者（n=293）中评估血浆MIC-1、全身炎症（定义为血浆C-反应蛋白（CRP）≥ 10 mg l-1或改良格拉斯哥预后评分（mGPS）≥ 10 mg l-1）和营养状况。健康志愿者（n=35）作为对照。与对照组（中位数= 377 pg ml-1;范围141 -3786; P<0.001）相比，患者的MIC-1升高（中位数= 1371 pg ml-1;范围141 - 39053）。胃肿瘤患者（中位数=1592 pg ml-1;范围141-12 643）的MIC-1浓度高于交界性肿瘤患者（中位数=1337 pg ml-1;范围383-39 053）和食管肿瘤患者（中位数=1180 pg ml-1;范围258-31 184; P=0.015）。患者体重减轻的中位数为6.4%（范围0.0-33.4%），42%的患者的mGPS为≥ 1或血浆CRP为≥ 10 mg l-1（中位数=9 mg l-1;范围1-200）。MIC-1与疾病分期（r2=0.217; P<0.001）、年龄（r2=0.332; P<0.001）、CRP（r2=0.314; P<0.001）和mGPS（r2=0.336; P<0.001）呈正相关，与Karnofsky功能评分呈负相关（r2=-0.269; P<0.001）。然而，尽管MIC-1与饮食摄入量弱相关（r2=0.157; P=0.031），但与体重减轻、BMI或人体测量学无关。MIC-1水平在上四分位数的患者与MIC-1水平在下三个四分位数的患者（中位数=316天; 95% CI 259-373; P=0.036）相比，生存期缩短（中位数=204天; 95% CI 157-251），但MIC-1不是独立的预后指标。OGC患者血浆MIC-1水平与营养状况或生存率之间无独立联系。
Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago-gastric cancer (OGC). Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of ⩾10 mg l–1 or modified Glasgow prognostic score (mGPS) of ⩾1), and nutritional status were assessed in newly diagnosed OGC patients (n=293). Healthy volunteers (n=35) served as controls. MIC-1 was elevated in patients (median=1371 pg ml–1; range 141–39 053) when compared with controls (median=377 pg ml–1; range 141–3786; P<0.001). Patients with gastric tumours (median=1592 pg ml–1; range 141–12 643) showed higher MIC-1 concentrations than patients with junctional (median=1337 pg ml–1; range 383–39 053) and oesophageal tumours (median=1180 pg ml–1; range 258–31 184; P=0.015). Patients showed a median weight loss of 6.4% (range 0.0–33.4%), and 42% of patients had an mGPS of ⩾1 or plasma CRP of ⩾10 mg l–1 (median=9 mg l–1; range 1–200). MIC-1 correlated positively with disease stage (r2=0.217; P<0.001), age (r2=0.332; P<0.001), CRP (r2=0.314; P<0.001), and mGPS (r2=0.336; P<0.001), and negatively with Karnofsky Performance Score (r2=−0.269; P<0.001). However, although MIC-1 correlated weakly with dietary intake (r2=0.157; P=0.031), it did not correlate with weight loss, BMI, or anthropometry. Patients with MIC-1 levels in the upper quartile showed reduced survival (median=204 days; 95% CI 157–251) when compared with patients with MIC-1 levels in the lower three quartiles (median=316 days; 95% CI 259–373; P=0.036), but MIC-1 was not an independent prognostic indicator. There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.
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