Common immune-related exposures/conditions and risk of non-Hodgkin lymphoma: a case-control study of disease-discordant twin pairs.
Common immune-related exposures/conditions and risk of non-Hodgkin lymphoma: a case-control study of disease-discordant twin pairs.
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常见的免疫相关暴露/状况和非霍奇金淋巴瘤的风险：疾病不一致双胞胎的病例对照研究。
DOI：
10.1093/aje/kwv053
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发表时间：
2015
影响因子：
5
通讯作者：
Cozen,Wendy
中科院分区：
文献类型：
--
作者：
Wang,Jun;Mack,ThomasM;Hamilton,AnnS;Hwang,AmieE;Nathwani,BharatN;Masood,Kamil;Buchanan,LauraH;Bernstein,Leslie;Deapen,DennisM;Martínez-Maza,Otoniel;Cozen,Wendy
We evaluated the association between common immune system–altering experiences and non-Hodgkin lymphoma (NHL) risk using a case-control study of 162 like-sex twin pairs discordant for NHL, identified from the International Twin Study. Information on medical history and evidence of childhood exposure to microbes was obtained by questionnaire from 1998 to 2002. Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals. Intra-twin-pair agreement between twins on individual exposures was high (76%–97%). A negative association between NHL and seasonal hay fever (odds ratio (OR) = 0.28, 95% confidence interval (CI): 0.10, 0.75) and certain allergies (OR = 0.29, 95% CI: 0.13, 0.68) was observed. The number of atopic diseases was negatively associated with NHL (Pfor trend = 0.0003). A history of infectious mononucleosis was negatively associated with NHL risk (OR = 0.35, 95% CI: 0.14, 0.90). NHL risk was associated with more frequent childhood exposure to microbes during early life (Pfor trend = 0.04). No differences in association by NHL subtype were observed, although statistical power for these comparisons was low. These observations support the hypothesis that immune-related exposures, especially atopy, are associated with decreased NHL risk. Use of the within-twin-pair study design mitigates confounding by genome, family structure, and unmeasured characteristics of early childhood factors.
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流行病学证据：IgE、过敏和造血系统恶性肿瘤
影响因子：
--
作者：
O. Martínez;A. Moreno;W. Cozen
通讯作者：
W. Cozen
扁桃体切除术、阑尾切除术和恶性淋巴瘤。
DOI：
10.1111/j.1600-0609.1982.tb02121.x
发表时间：
2009
期刊：
Scandinavian journal of haematology
影响因子：
--
作者：
V. Silingardi;L. Venezia;A. Tampieri;C. Gramolini
通讯作者：
C. Gramolini
儿童社会环境与成人非霍奇金淋巴瘤的风险。
影响因子：
11.2
作者：
Smedby,KarinEkstrom;Hjalgrim,Henrik;Chang,EllenT;Rostgaard,Klaus;Glimelius,Bengt;Adami,Hans-Olov;Melbye,Mads
通讯作者：
Melbye,Mads
影响因子：
5
作者：
Skibola, Christine F.;Bracci, Paige M.;Wang, Sophia S.
通讯作者：
Wang, Sophia S.
影响因子：
2.3
作者：
Fabbro-Peray, P;Daures, JP;Rossi, JF
通讯作者：
Rossi, JF