Epidemiological Evidence: IgE, Allergies, and Hematopoietic Malignancies
Epidemiological Evidence: IgE, Allergies, and Hematopoietic Malignancies
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流行病学证据：IgE、过敏和造血系统恶性肿瘤
DOI：
10.1007/978-1-60761-451-7_5
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发表时间：
2010
影响因子：
--
通讯作者：
W. Cozen
中科院分区：
文献类型：
--
作者：
O. Martínez;A. Moreno;W. Cozen
This chapter presents an overview of recent epidemiologic studies that address the association between atopic diseases and IgE and the risk of hematopoietic cancers, including a discussion of potential biological mechanisms. The strongest and most consistent (inverse) associations have been observed between allergic conditions and childhood leukemia, especially acute lymphoblastic leukemia. The cumulative evidence for an inverse association between atopy and non-Hodgkin lymphoma is suggestive, but the inconsistency of the associations with specific types of atopic conditions, the lack of any associations observed in most cohort studies, and the correlation between timing of diagnosis and decreasing IgE levels warrant further clarification. No consistent evidence has been found supporting an association between atopy and either plasma cell neoplasms or Hodgkin lymphoma.
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