Multifunctional Laryngeal Premotor Neurons: Their Activities during Breathing, Coughing, Sneezing, and Swallowing
Multifunctional Laryngeal Premotor Neurons: Their Activities during Breathing, Coughing, Sneezing, and Swallowing
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多功能喉前运动神经元：呼吸、咳嗽、打喷嚏和吞咽期间的活动
DOI：
10.1523/jneurosci.0001-07.2007
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
T. Umezaki
中科院分区：
文献类型：
--
作者：
K. Shiba;K. Nakazawa;K. Ono;T. Umezaki
为了检查两个或多个不同喉部运动模式的运动命令是否会聚到一个共同的运动前网络上，我们对去大脑瘫痪猫的虚构呼吸、咳嗽、打喷嚏和吞咽期间脑干呼吸回路内的喉内收肌运动神经元及其前运动神经元进行了双重记录。具有增强放电模式（EAUG）的呼气神经元，其动作电位会诱发内收肌运动神经元中的单突触 IPSP，在虚构的咳嗽和打喷嚏的呼气阶段急剧放电，在此期间内收肌运动神经元短暂复极化。相反，这些前运动神经元在内收肌运动神经元的吞咽相关超极化过程中保持沉默。这些结果表明，一类髓质呼吸神经元（EAUG）具有多功能性，并在呼吸、咳嗽和打喷嚏的中枢模式发生器（CPG）之间共享。此外，虽然这三种行为背后的 CPG 和吞咽 CPG 确实重叠，但 EAUG 神经元不是吞咽 CPG 的一部分，并且与其他三种行为相反，它不是吞咽过程中内收肌运动神经元的抑制输入来源。
To examine whether motor commands of two or more distinct laryngeal motor patterns converge onto a common premotor network, we conducted dual recordings from the laryngeal adductor motoneuron and its premotor neuron within the brainstem respiratory circuitry during fictive breathing, coughing, sneezing, and swallowing in decerebrate paralyzed cats. Expiratory neurons with an augmenting firing pattern (EAUG), whose action potentials evoked monosynaptic IPSPs in the adductor motoneurons, sharply fired during the expulsive phases of fictive coughing and sneezing, during which the adductor motoneurons transiently repolarized. In contrast, these premotor neurons were silent during the swallow-related hyperpolarization in adductor motoneurons. These results show that one class of medullary respiratory neuron, EAUG, is multifunctional and shared among the central pattern generators (CPGs) for breathing, coughing, and sneezing. In addition, although the CPGs underlying these three behaviors and the swallowing CPG do overlap, EAUG neurons are not part of the swallowing CPG and, in contrast to the other three behaviors, are not a source of inhibitory input to adductor motoneurons during swallowing.
呕吐期间腹部和呼气肋间肌活动的控制：腹侧呼吸组呼气神经元的作用。
影响因子：
2.5
作者：
Miller,AD;Tan,LK;Suzuki,I
通讯作者：
Suzuki,I
喉传入对呼气球脊髓神经元和运动神经元的影响。
DOI：
10.1152/jappl.1988.64.4.1337
发表时间：
1988
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Jodkowski,JS;Berger,AJ
通讯作者：
Berger,AJ