Functionally and structurally distinct fusiform face area(s) in over 1000 participants.

Functionally and structurally distinct fusiform face area(s) in over 1000 participants.
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DOI:
10.1016/j.neuroimage.2022.119765
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发表时间:
2023-01
期刊:
影响因子:
5.7
通讯作者:
Weiner, Kevin S.
Weiner, Kevin S.
中科院分区:
医学1区
文献类型:
--
作者:
Chen, Xiayu;Liu, Xingyu;Parker, Benjamin J.;Zhen, Zonglei;Weiner, Kevin S.

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梭形面部区域(FFA)是一个被广泛研究的与面部感知相关的区域。尽管认知神经科学家研究 FFA 已经有二十多年了,但仍然缺乏来自大量 (N>1000) 参与者的关于 FFA 功能、架构和连接性的基本问题的答案。为了填补这一知识空白,我们对人类连接组项目 1053 名参与者的梭形面部选择性区域的多模态特征进行了量化。在手动定义 4,000 多个梭形面部选择性区域后,我们报告了五个主要发现。首先,68.76% 的半球有两个皮质独立区域(pFus-faces/FFA-1 和 mFus-faces/FFA-2)。其次,在 26.69% 的半球中,pFus-faces/FFA-1 和 mFus-faces/FFA-2 在空间上是连续的,但在功能、架构和连接性指标上是不同的。第三,pFus-faces/FFA-1 比 mFus-faces/FFA-2 更具面部选择性,并且这两个区域具有不同的功能连接指纹。第四,pFus-faces/FFA-1 的皮质比 mFus-faces/FFA-2 更薄,髓鞘更厚。第五,每个区域的面部选择模式和功能连接指纹在同卵双胞胎中比异卵双胞胎更相似,并且比结构梯度更相似。当我们与该领域分享我们的区域定义时,未来的研究可以探索这些区域的结构和功能特征如何为有关视觉类别在大脑中如何表示的理论提供信息。
The fusiform face area (FFA) is a widely studied region causally involved in face perception. Even though cognitive neuroscientists have been studying the FFA for over two decades, answers to foundational questions regarding the function, architecture, and connectivity of the FFA from a large (N>1000) group of participants are still lacking. To fill this gap in knowledge, we quantified these multimodal features of fusiform face-selective regions in 1053 participants in the Human Connectome Project. After manually defining over 4,000 fusiform face-selective regions, we report five main findings. First, 68.76% of hemispheres have two cortically separate regions (pFus-faces/FFA-1 and mFus-faces/FFA-2). Second, in 26.69% of hemispheres, pFus-faces/FFA-1 and mFus-faces/FFA-2 are spatially contiguous, yet are distinct based on functional, architectural, and connectivity metrics. Third, pFus-faces/FFA-1 is more face-selective than mFus-faces/FFA-2, and the two regions have distinct functional connectivity fingerprints. Fourth, pFus-faces/FFA-1 is cortically thinner and more heavily myelinated than mFus-faces/FFA-2. Fifth, face-selective patterns and functional connectivity fingerprints of each region are more similar in monozygotic than dizygotic twins and more so than architectural gradients. As we share our areal definitions with the field, future studies can explore how structural and functional features of these regions will inform theories regarding how visual categories are represented in the brain.
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