Examination of the relationships between jaw opener and closer rhythmical muscle activity in an in vitro brainstem jaw-attached preparation.
Examination of the relationships between jaw opener and closer rhythmical muscle activity in an in vitro brainstem jaw-attached preparation.
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在体外脑干颌附着制剂中检查颌张开器和更接近的节律性肌肉活动之间的关系。
DOI：
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发表时间：
1998
影响因子：
0.9
通讯作者：
T. Matsuya
中科院分区：
文献类型：
--
作者：
M. Kogo;S. Tanaka;S. H. Chandler;T. Matsuya
开发了一种体外下颌附着脑干制剂，以研究化学诱导新生大鼠有节奏的下颌运动期间下颌张开和闭合肌肉活动之间的关系。在大多数检查的准备工作中，脑干的特定区域被隔离，并且开颌肌和闭合肌的神经元神经支配保持完整，兴奋性氨基酸激动剂 N-甲基-D,L-天冬氨酸（NMA，20-40 µM）与荷包牡丹碱（BIC 10 µM）（一种 GABA（A）拮抗剂）组合的浴应用，在开颌肌和闭合肌中产生了节律性肌电图（EMG）活动，双侧，结合有节奏的下颌运动。低浓度的 NMA (20 µM) 与 BIC 结合可在同侧的开颌肌和闭合肌之间产生暂时协调的活动。使用较高剂量的 NMA（40 微摩尔）时，每个肌肉群都表现出爆发性，但它们之间的时间协调很难建立。类似地，NMA 与甘氨酸拮抗剂马钱子碱（STR，10 µM）联合应用，也在同侧的开放肌肉和闭合肌肉中产生有节律的肌电图活动，但拮抗肌肉对之间没有显示时间协调。然而，通过在浴液中添加 BIC 可以恢复开场肌和闭场肌放电的协调性。我们认为，存在独立但协调的节律发生器电路，用于打开和关闭运动神经元放电，位于三叉神经运动核附近，并在 GABA 能控制下，在节律发生电路之间产生时间协调。
An in vitro jaw-attached brainstem preparation was developed to investigate the relationship between jaw opener and closer muscle activity during chemically induced rhythmical jaw movements in neonatal rats. In the majority of preparations examined, where a defined region of brainstem was isolated and the neuronal innervation of the jaw opener and closer muscles was left intact, bath application of the excitatory amino acid agonist N-methyl-D,L-aspartate (NMA, 20-40 microM) in combination with bicuculline (BIC 10 microM), a GABA(A) antagonist, produced rhythmical electromyogram (EMG) activity in jaw opener and closer muscles, bilaterally, in conjunction with rhythmical jaw movements. Low concentrations of NMA (20 microM) in combination with BIC produced temporally coordinated activity between the jaw opener and closer muscles, ipsilaterally. With higher doses of NMA (40 microM), each muscle group exhibited bursting, but temporal coordination between them was difficult to establish. Similarly, NMA application in combination with the glycine antagonist strychnine (STR, 10 microM), also produced rhythmical EMG activity from both opener and closer muscles, ipsilaterally, but showed no temporal coordination between the antagonist muscle pair. However, coordination of opener and closer muscle discharge could be restored by the addition of BIC to the bath. We suggest that there exist separate, but coordinated, rhythm generator circuits for opener and closer motoneuronal discharge located in close proximity to the trigeminal motor nucleus and under GABAergic control for production of temporal coordination between rhythmogenic circuits.
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