Genetic variants in vitamin d pathway genes and risk of pancreas cancer; results from a population-based case-control study in ontario, Canada.
Genetic variants in vitamin d pathway genes and risk of pancreas cancer; results from a population-based case-control study in ontario, Canada.
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维生素D途径基因的遗传变异和胰腺癌的风险；来自加拿大安大略省的基于人群的病例对照研究的结果。
DOI：
10.1371/journal.pone.0066768
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Cleary SP
中科院分区：
文献类型：
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作者：
Anderson LN;Cotterchio M;Knight JA;Borgida A;Gallinger S;Cleary SP
最近对 25-羟基维生素 D (25(OH)D) 水平和胰腺癌的研究表明，维生素 D 途径在这种致命疾病的病因学中具有潜在作用。已知维生素 D 相关基因的变异会影响 25(OH)D 水平和功能，但尚不清楚这些变异是否会影响胰腺癌风险。安大略省胰腺癌研究（一项基于人群的病例对照研究）评估了 11 个基因中 87 个单核苷酸多态性 (SNP) 之间的关联。病理证实为腺癌的胰腺癌病例从安大略省癌症登记处确定（n = 628），并通过随机数字拨号确定对照（n = 1193）。通过多元逻辑回归估计年龄和性别调整后的比值比 (OR) 和 95% 置信区间 (CI)。 CYP24A1、CYP2R1、钙敏感受体 (CASR)、维生素 D 结合蛋白 (GC)、视黄醇 X 受体-α (RXRA) 和巨蛋白 (LRP2) 基因中的 SNP 与胰腺癌风险显着相关。例如，胰腺癌风险与 CYP2R1 rs10741657 呈负相关（AA 与 GG，OR = 0.70；95%CI：0.51–0.95），与 CYP24A1 rs6127119 呈正相关（TT 与 CC。OR = 1.94；95%CI： 1.28–2.94）。经过多重比较调整后，这些关联均不具有统计学显着性。维生素 D 通路基因变异可能与胰腺癌风险相关，需要未来的研究来了解维生素 D 在肿瘤发生中的可能作用，并可能对癌症预防策略产生影响。
Recent studies of 25-hydroxyvitamin D (25(OH)D) levels and pancreas cancer have suggested a potential role of the vitamin D pathway in the etiology of this fatal disease. Variants in vitamin-D related genes are known to affect 25(OH)D levels and function and it is unknown if these variants may influence pancreatic cancer risk. The association between 87 single nucleotide polymorphisms (SNPs) in 11 genes was evaluated within the Ontario Pancreas Cancer Study, a population-based case-control study. Pancreatic cancer cases with pathology confirmed adenocarcinoma were identified from the Ontario Cancer Registry (n = 628) and controls were identified through random digit dialing (n = 1193). Age and sex adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated by multivariate logistic regression. SNPs in the CYP24A1, CYP2R1, calcium sensing receptor (CASR), vitamin D binding protein (GC), retinoid X receptor-alpha (RXRA) and megalin (LRP2) genes were significantly associated with pancreas cancer risk. For example, pancreas cancer risk was inversely associated with CYP2R1 rs10741657 (AA versus GG, OR = 0.70; 95%CI: 0.51–0.95) and positively with CYP24A1 rs6127119 (TT versus CC. OR = 1.94; 95%CI: 1.28–2.94). None of the associations were statistically significant after adjustment for multiple comparisons. Vitamin D pathway gene variants may be associated with pancreas cancer risk and future studies are needed to understand the possible role of vitamin D in tumorigenesis and may have implications for cancer-prevention strategies.
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影响因子：
2.3
作者：
Anderson, Laura N.;Cotterchio, Michelle;Gallinger, Steven
通讯作者：
Gallinger, Steven
影响因子：
3.5
作者：
Ahn J;Yu K;Stolzenberg-Solomon R;Simon KC;McCullough ML;Gallicchio L;Jacobs EJ;Ascherio A;Helzlsouer K;Jacobs KB;Li Q;Weinstein SJ;Purdue M;Virtamo J;Horst R;Wheeler W;Chanock S;Hunter DJ;Hayes RB;Kraft P;Albanes D
通讯作者：
Albanes D
影响因子：
3.6
作者：
Schwartz, Gary G.;Eads, Dawn;Koumenis, Constantinos
通讯作者：
Koumenis, Constantinos
影响因子：
3.8
作者：
Dong, Linda M.;Ulrich, Cornelia M.;Hsu, Li;Duggan, David J.;Benitez, Debbie S.;White, Emily;Slattery, Martha L.;Caan, Bette J.;Potter, John D.;Peters, Ulrike
通讯作者：
Peters, Ulrike
影响因子：
8.8
作者：
通讯作者：
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