Lifestyle, dietary, and medical history factors associated with pancreatic cancer risk in Ontario, Canada.
Lifestyle, dietary, and medical history factors associated with pancreatic cancer risk in Ontario, Canada.
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DOI：
10.1007/s10552-009-9303-5
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发表时间：
2009-08
影响因子：
2.3
通讯作者：
Gallinger, Steven
中科院分区：
文献类型：
--
作者：
Anderson, Laura N.;Cotterchio, Michelle;Gallinger, Steven
胰腺癌是所有癌症中生存率最低的癌症之一。这种恶性肿瘤的既定危险因素是吸烟，体重指数（BMI）和胰腺癌家族史。在胰腺炎、糖尿病、过敏、水果、蔬菜、红肉、酒精、咖啡因、维生素C、钙和叶酸补充剂的摄入方面，研究结果不一致。在基于人群的安大略胰腺癌研究中评估了可能的胰腺癌风险因素。病理证实的胰腺癌病例（n = 422）是从2003年至2007年期间的安大略癌症登记处确定的。通过随机数字拨号招募对照组（n = 312）。使用自填问卷收集数据。采用多变量logistic回归分析获得优势比。吸烟、BMI、胰腺癌家族史和咖啡因与胰腺癌风险增加显著相关，而水果摄入和过敏显著降低风险。在多变量模型中未观察到其他显著相关性。吸烟状况对咖啡因、胰腺癌家族史、BMI和水果的影响有影响。这项研究进一步阐明了几种生活方式，饮食和病史因素与胰腺癌风险之间的关系，其中许多因素是可以改变的。在未来的病因学研究中，应进一步探讨吸烟状态可能的影响。
Pancreatic adenocarcinoma has one of the worst survival rates of all the cancers. Established risk factors for this malignancy are smoking, body mass index (BMI) and family history of pancreatic cancer. Findings are inconsistent regarding pancreatitis, diabetes, allergies, intake of fruit, vegetables, red meat, alcohol, caffeine, vitamin C, calcium, and folate supplements. Possible pancreatic cancer risk factors were evaluated within the population-based Ontario Pancreas Cancer Study. Pathologically confirmed pancreatic cancer cases (n = 422) were identified from the Ontario Cancer Registry between 2003 and 2007. Controls (n = 312) were recruited through random digit dialing. Data were collected using self-administered questionnaires. Multivariate logistic regression was used to obtain odds ratios. Smoking, BMI, family history of pancreatic cancer, and caffeine were significantly associated with increased pancreatic cancer risk, while fruit intake and allergies significantly decreased risk. No other significant associations were observed in the multivariate model. Effect modification by smoking status was suggested for caffeine, family history of pancreatic cancer, BMI, and fruit. This study further clarifies the association between several lifestyle, dietary and medical history factors, and pancreatic cancer risk, many of which are potentially modifiable. Possible effect modification by smoking status should be further explored in future etiologic studies.
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