Analysis of T and NK cell subsets in the Sicilian population from young to supercentenarian: The role of age and gender.
Analysis of T and NK cell subsets in the Sicilian population from young to supercentenarian: The role of age and gender.
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DOI：
10.1111/cei.13606
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发表时间：
2021-08
影响因子：
4.6
通讯作者：
Candore G
中科院分区：
文献类型：
--
作者：
Ligotti ME;Aiello A;Accardi G;Aprile S;Bonura F;Bulati M;Gervasi F;Giammanco GM;Pojero F;Zareian N;Caruso C;Farzaneh F;Candore G
老龄化极大地影响了免疫系统先天和适应性武器的数量和功能，特别是T细胞亚群，导致疫苗接种效力降低，对感染的抵抗力下降，老年人癌症患病率增加。在本文中，我们分析了214名西西里受试者淋巴细胞绝对数量的年龄相关变化，以及供体亚群中T和自然杀伤（NK）细胞的百分比。我们将这些结果与最年长的意大利超级百岁老人（111岁）的免疫表型进行了比较。结果也按性别排序。所有个体中细胞数量/百分比与年龄之间的相关性。并分别在男性和女性中，使用简单线性回归分析进行了检查。我们没有记录到CD 4/CD 8比值倒置率的增加，这在文献中经常被报道为与衰老相关。我们的观察结果是老龄供体中CD 4+和CD 8 + T细胞百分比平均趋势持平的直接结果，即使包括性别差异。我们的研究结果还表明，CD 4+和CD 8+亚群不受年龄的影响，女性与男性相比，我们推测，性别可能会影响巨细胞病毒（CMV）感染的反应。超百岁老人表现出独特的免疫表型特征，关于她的T细胞亚群的相对百分比，与CD 4+和CD 8 + T细胞百分比和CD 4+幼稚T细胞值与记录的百岁老人的主题。这表明超级百岁老人具有与>80岁女性相当的幼稚“年轻”T细胞特征。我们研究了216名西西里受试者（年龄范围22 - 111岁）中淋巴细胞绝对数量的年龄相关变化，以及不同年龄的较小供体组中循环淋巴细胞亚群百分比的变化。还按性别分析了数据。超级百岁老人的T细胞特征与老年女性相当。
Ageing dramatically affects number and function of both innate and adaptive arms of immune system, particularly T cell subsets, contributing to reduced vaccination efficacy, decreased resistance to infections and increased prevalence of cancer in older people. In the present paper, we analysed the age‐related changes in the absolute number of lymphocytes in 214 Sicilian subjects, and in the percentages of T and natural killer (NK) cells in a subcohort of donors. We compared these results with the immunophenotype of the oldest living Italian supercentenarian (aged 111 years). The results were also sorted by gender. The correlation between number/percentage of cells and age in all individuals. and separately in males and females, was examined using a simple linear regression analysis. We did not record the increase in the rate of inversion of the CD4/CD8 ratio, frequently reported as being associated with ageing in literature. Our observation was the direct consequence of a flat average trend of CD4+ and CD8+ T cell percentages in ageing donors, even when gender differences were included. Our results also suggest that CD4+ and CD8+ subsets are not affected equally by age comparing females with males, and we speculated that gender may affect the response to cytomegalovirus (CMV) infection. The supercentenarian showed a unique immunophenotypic signature regarding the relative percentages of her T cell subsets, with CD4+ and CD8+ T cell percentages and CD4+ naive T cell values in line with those recorded for the octogenarian subjects. This suggests that the supercentenarian has a naive ‘younger’ T cell profile comparable to that of a >80‐year‐old female. We investigated age‐related changes in the absolute number of lymphocytes among 216 Sicilian subjects (age range 22‐111) and in the percentages of circulating lymphocyte subsets in a smaller group of donors of different ages. The data were also analyzed by gender. The supercentenarian has a naïve ‘younger’ T cell profile comparable to that of an older female.
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影响因子：
7.4
作者：
Aiello A;Accardi G;Aprile S;Caldarella R;Carru C;Ciaccio M;De Vivo I;Gambino CM;Ligotti ME;Vasto S;Zinellu A;Caruso C;Bono F;Candore G
通讯作者：
Candore G
影响因子：
17.1
作者：
Clave, Emmanuel;Araujo, Itaua Leston;Toubert, Antoine
通讯作者：
Toubert, Antoine
DOI：
10.1093/gerona/glr223
发表时间：
2012-04-01
影响因子：
5.1
作者：
Andersen, Stacy L.;Sebastiani, Paola;Perls, Thomas T.
通讯作者：
Perls, Thomas T.
影响因子：
4.4
作者：
Derhovanessian, Evelyna;Maier, Andrea B.;Pawelec, Graham
通讯作者：
Pawelec, Graham
影响因子：
13.1
作者：
Lio D;Scola L;Giarratana RM;Candore G;Colonna-Romano G;Caruso C;Balistreri CR
通讯作者：
Balistreri CR