SARS CoV2 infection _The longevity study perspectives.
SARS CoV2 infection _The longevity study perspectives.
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DOI：
10.1016/j.arr.2021.101299
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发表时间：
2021-05
影响因子：
13.1
通讯作者：
Balistreri CR
中科院分区：
文献类型：
--
作者：
Lio D;Scola L;Giarratana RM;Candore G;Colonna-Romano G;Caruso C;Balistreri CR
与其他传染病一样，COVID-19的临床结果差异很大，从无症状到致命。在意大利，与其他国家一样，患有一种或多种合并症的老年男性是最易感群体，因此死亡率和发病率最高，包括致命的呼吸窘迫综合征，是最常见的并发症。此外，另一个非凡的特点是对COVID-19的惊人抵抗力，这是一些意大利九十岁/百岁老人的特点。尽管具有典型的COVID-19体征和/或症状，但这些特殊的个体显示出令人惊讶的从疾病和并发症中恢复的趋势。另一方面，长寿的人具有与免疫/炎症基因中抗炎变体的过表达相关的免疫系统的最佳性能，正如我们和其他小组所证明的那样。因此，我们建议长寿的人作为检测与COVID-19易感性和/或保护相关的遗传谱的最佳模型，以用作预防或减少更脆弱个体病毒感染的潜在药理学靶点。
Like other infectious diseases, COVID-19 shows a clinical outcome enormously variable, ranging from asymptomatic to lethal. In Italy, like in other countries, old male individuals, with one or more comorbidity, are the most susceptible group, and show, consequently, the highest mortality, and morbidity, including lethal respiratory distress syndrome, as the most common complication. In addition, another extraordinary peculiarity, that is a surprising resistance to COVID-19, characterizes some Italian nonagenarians/centenarians. Despite having the typical COVID-19 signs and/or symptoms, such exceptional individuals show a surprising tendency to recover from illness and complications. On the other hand, long-lived people have an optimal performance of immune system related to an overexpression of anti-inflammatory variants in immune/inflammatory genes, as demonstrated by our and other groups. Consequently, we suggest long-lived people as an optimal model for detecting genetic profiles associated with the susceptibility and/or protection to COVID-19, to utilize as potential pharmacological targets for preventing or reducing viral infection in more vulnerable individuals.
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影响因子：
--
作者：
Albani, Diego;Ateri, Eleonora;Forloni, Gianluigi
通讯作者：
Forloni, Gianluigi
DOI：
10.1196/annals.1386.051
发表时间：
2006-01-01
期刊：
ESTROGENS AND HUMAN DISEASES
影响因子：
--
作者：
Candore, Giuseppina;Balistreri, Carmela R.;Caruso, Calogero
通讯作者：
Caruso, Calogero
影响因子：
4.6
作者：
Balistreri CR
通讯作者：
Balistreri CR
影响因子：
7.3
作者：
Chi, Hongbo;Flavell, Richard A.
通讯作者：
Flavell, Richard A.
DOI：
10.1196/annals.1395.014
发表时间：
2007-01-01
期刊：
BIOGERONTOLOGY: MECHANISMS AND INTERVENTIONS
影响因子：
--
作者：
Balistreri, Carmela Rita;Caruso, Calogero;Candore, Giuseppina
通讯作者：
Candore, Giuseppina