Functional Networks in Disorders of Consciousness.
Functional Networks in Disorders of Consciousness.
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DOI：
10.1055/s-0037-1607310
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发表时间：
2017-10
影响因子：
2.7
通讯作者：
Edlow BL
中科院分区：
文献类型：
--
作者：
Bodien YG;Chatelle C;Edlow BL
严重的脑损伤可能会导致维持觉醒和意识的神经网络中断，这是意识的两个基本组成部分。尽管有潜在的破坏性的直接和长期后果，意识障碍（DoC）的基本神经生物学，病理生理学和恢复之间的关系，以及治疗效果的预测因素方面了解甚少。神经影像学技术的最新进展现在使网络连接的研究成为可能，为改善DoC患者的临床护理提供了巨大的潜力。该领域的初步发现是使用正电子发射断层扫描（PET）取得的。最近，功能性磁共振（fMRI）技术增加了我们对这一人群的功能网络动力学的理解。这两种方法都表明，与健康受试者相比，DoC患者无论是在休息时还是在执行目标导向的任务时，处理内在思想和外在刺激所必需的功能网络都受到了破坏。在默认模式网络以及意识可能需要的其他皮层和皮层下网络中，非典型连接已经很好地建立起来。此外，连接改变的程度可能与意识受损的严重程度有关，并且意识的恢复已被证明与连接的恢复有关。在这篇综述中，我们讨论了PET和功能磁共振成像研究的功能和有效的连接在DoC患者，并建议如何在未来这一领域可以走向临床应用的功能网络映射。
Severe brain injury may cause disruption of neural networks that sustain arousal and awareness, the two essential components of consciousness. Despite the potentially devastating immediate and long-term consequences, disorders of consciousness (DoC) are poorly understood in terms of their underlying neurobiology, the relationship between pathophysiology and recovery, and the predictors of treatment efficacy. Recent advances in neuroimaging techniques now enable the study of network connectivity, providing great potential to improve the clinical care of patients with DoC. Initial discoveries in this field were made using positron emission tomography (PET). More recently, functional magnetic resonance (fMRI) techniques have added to our understanding of functional network dynamics in this population. Both methods have shown that whether at rest or performing a goal-oriented task, functional networks essential for processing intrinsic thoughts and extrinsic stimuli are disrupted in patients with DoC compared with healthy subjects. Atypical connectivity has been well established in the default mode network as well as in other cortical and subcortical networks that may be required for consciousness. Moreover, the degree of altered connectivity may be related to the severity of impaired consciousness, and recovery of consciousness has been shown to be associated with restoration of connectivity. In this review, we discuss PET and fMRI studies of functional and effective connectivity in patients with DoC, and suggest how this field can move towards clinical application of functional network mapping in the future.
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影响因子：
2.9
作者：
Brooks JC;Faull OK;Pattinson KT;Jenkinson M
通讯作者：
Jenkinson M
影响因子：
5.3
作者：
Cavaliere C;Aiello M;Di Perri C;Amico E;Martial C;Thibaut A;Laureys S;Soddu A
通讯作者：
Soddu A
影响因子：
--
作者：
Boly, M;Faymonville, ME;Laureys, S
通讯作者：
Laureys, S
DOI：
10.1007/s10334-016-0546-3
发表时间：
2016-06-01
影响因子：
2.3
作者：
Bianciardi, Marta;Toschi, Nicola;Wald, Lawrence L.
通讯作者：
Wald, Lawrence L.
影响因子：
48
作者：
Boly, Melanie;Faymonville, Marie-Elisabeth;Laureys, Steven
通讯作者：
Laureys, Steven