Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients.
Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients.
复制标题
DOI：
10.3389/fncel.2016.00257
复制
发表时间：
2016
影响因子：
5.3
通讯作者：
Soddu A
中科院分区：
文献类型：
--
作者：
Cavaliere C;Aiello M;Di Perri C;Amico E;Martial C;Thibaut A;Laureys S;Soddu A
经颅直流电刺激（tDCS）是一种非侵入性技术，最近被应用于意识障碍，并在几乎一半的最低意识状态（MCS）患者中确定意识体征的短暂恢复。尽管越来越多的证据表明它可能在许多神经和精神疾病的治疗中发挥作用，但没有证据表明tDCS反应背后的脑功能连接底物。在一项双盲随机交叉试验中，我们回顾性评估了16名亚急性和慢性MCS患者（6名tDCS应答者）的静息状态功能磁共振成像（fMRI），这些患者先后接受了单一的左背外侧前额叶皮层（DLPFC） tDCS。对左外部控制网络（ECN）和默认模式网络（DMN）的区域进行了基于种子的求解。tDCS应答者显示与左侧DLPFC共同激活的区域的左侧网络内连通性增加，并且与左侧额下回显著增加。无反应（NR） MCS患者显示左侧DLPFC与中线皮质结构（包括前扣带皮层和楔前叶）之间的连通性增加。我们的研究结果表明，在接受tDCS治疗的MCS患者亚组中，与属于ECN的区域的先前高连通性可以促进短暂的意识恢复。因此，静息状态fmri在检测tDCS改善MCS行为所需的神经元条件方面非常有价值。
Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients. Although the rising evidences about its possible role in the treatment of many neurological and psychiatric conditions exist, no evidences exist about brain functional connectivity substrates underlying tDCS response. We retrospectively evaluated resting state functional Magnetic Resonance Imaging (fMRI) of 16 sub-acute and chronic MCS patients (6 tDCS responders) who successively received a single left dorsolateral prefrontal cortex (DLPFC) tDCS in a double-blind randomized cross-over trial. A seed-based approach for regions of left extrinsic control network (ECN) and default-mode network (DMN) was performed. tDCS responders showed an increased left intra-network connectivity for regions co-activated with left DLPFC, and significantly with left inferior frontal gyrus. Non-responders (NR) MCS patients showed an increased connectivity between left DLPFC and midline cortical structures, including anterior cingulate cortex and precuneus. Our findings suggest that a prior high connectivity with regions belonging to ECN can facilitate transitory recovery of consciousness in a subgroup of MCS patients that underwent tDCS treatment. Therefore, resting state-fMRI could be very valuable in detecting the neuronal conditions necessary for tDCS to improve behavior in MCS.
登录
查看更多内容
影响因子：
1
作者：
Guldenmund, P.;Vanhaudenhuyse, A.;Soddu, A.
通讯作者：
Soddu, A.
影响因子：
4.4
作者：
Boggio, Paulo S.;Ferrucci, Roberta;Fregni, Felipe
通讯作者：
Fregni, Felipe
影响因子：
3.8
作者：
Heine L;Soddu A;Gómez F;Vanhaudenhuyse A;Tshibanda L;Thonnard M;Charland-Verville V;Kirsch M;Laureys S;Demertzi A
通讯作者：
Demertzi A
影响因子：
5.7
作者：
Aiello, Marco;Salvatore, Elena;Quarantelli, Mario
通讯作者：
Quarantelli, Mario
DOI：
10.1073/pnas.0611404104
发表时间：
2007-07-17
影响因子：
11.1
作者：
Boly, M.;Balteau, E.;Laureys, S.
通讯作者：
Laureys, S.