Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.
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DOI：
10.1002/mus.21485
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发表时间：
2010-03
期刊：
影响因子：
3.4
通讯作者：
Li, Zhongyu
中科院分区：
文献类型：
--
作者：
Apel, Peter J.;Ma, Jianjun;Callahan, Michael;Northam, Casey N.;Alton, Timothy B.;Sonntag, William E.;Li, Zhongyu
年龄是周围神经损伤后神经肌肉恢复的重要预测因素。胰岛素样生长因子1 （IGF-1）是一种有效的神经营养因子，已知随着年龄的增长而下降。本研究的目的是确定局部递送IGF-1是否会改善老年动物的神经再生和神经肌肉恢复。用生理盐水或IGF-1连续递送至神经修复部位，对年轻和老年大鼠进行神经横断和修复。3个月后，观察神经再生和神经肌肉连接形态。在幼龄和老年动物中，IGF-1均能显著改善轴突的数量、直径和密度。IGF-1还显著增加髓鞘形成和雪旺细胞活性，并保持突触后神经肌肉连接（NMJ）的形态。这些结果表明，衰老再生神经对IGF-1治疗敏感。
Age is an important predictor of neuromuscular recovery after peripheral nerve injury. Insulin-like growth factor 1 (IGF-1) is a potent neurotrophic factor that is known to decline with increasing age. The purpose of this study was to determine if locally delivered IGF-1 would improve nerve regeneration and neuromuscular recovery in aged animals. Young and aged rats underwent nerve transection and repair with either saline or IGF-1 continuously delivered to the site of the nerve repair. After 3 months, nerve regeneration and neuromuscular junction morphology were assessed. In both young and aged animals, IGF-1 significantly improved axon number, diameter, and density. IGF-1 also significantly increased myelination and Schwann cell activity and preserved the morphology of the postsynaptic neuromuscular junction (NMJ). These results show that aged regenerating nerve is sensitive to IGF-1 treatment.
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影响因子：
4.8
作者：
Rabinovsky, ED;Gelir, E;Schwartz, RJ
通讯作者：
Schwartz, RJ
影响因子：
2.8
作者：
Apel, Peter J.;Alton, Timothy;Northam, Casey;Ma, Jianjun;Callahan, Michael;Sonntag, William E.;Li, Zhongyu
通讯作者：
Li, Zhongyu
影响因子：
3.3
作者：
Markowska, AL;Mooney, M;Sonntag, WE
通讯作者：
Sonntag, WE
DOI：
10.1016/0169-328x(95)00116-a
发表时间：
1995-12-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
PU, SF;ZHUANG, HX;ISHII, DN
通讯作者：
ISHII, DN
影响因子：
1.9
作者：
Rabinovsky, ED
通讯作者：
Rabinovsky, ED